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Friday, November 7, 2025 2:10 AM

antibiotic resistance

AIIMS study reveals high prevalence of catheter-related infections in Indian hospitals

A nationwide study led by the All India Institute of Medical Sciences (AIIMS), New Delhi, has revealed that bloodstream infections linked to catheter use are widespread in intensive care units (ICUs) across India, with many cases caused by highly drug-resistant microbes. These hospital-acquired infections, known as Central Line-Associated Bloodstream Infections (CLABSI), occur when a catheter inserted into a large vein becomes contaminated. According to estimates published in The Lancet Global Health, Indian ICUs report nearly nine infection events for every 1,000 days a central line remains in use. The AIIMS-led team analysed seven years of data collected by the Indian Healthcare-Associated Infections (HAI) surveillance network, spanning 200 ICUs across 54 hospitals. Between May 2017 and April 2024, the network recorded 8,629 confirmed CLABSI cases, covering more than 3 million patient-days and nearly 1 million central line-days. The pooled CLABSI rate was found to be 8.83 per 1,000 central line-days. The study also observed a spike in infection rates during 2020–21, coinciding with the COVID-19 pandemic. Researchers attributed this surge to overburdened ICUs, staff shortages, and lapses in infection prevention practices. Experts stressed that while CLABSI is preventable, establishing systematic infection surveillance and prevention programs requires significant resources—a major challenge for low- and middle-income countries like India. Nevertheless, the findings mark the first large-scale, standardised surveillance report on CLABSI in India, offering a foundation for healthcare systems to adopt quality improvement measures. Source: PTI Photo Credit: AFP  

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Antibiotic-Resistant Infections Could Kill 40 Million by 2050, Study Warns

A new study published in The Lancet warns that nearly 40 million people could die from antibiotic-resistant infections by 2050, as antimicrobial resistance (AMR) continues to rise globally. The study, led by researchers from the Institute for Health Metrics and Evaluation at the University of Washington, found that deaths from antibiotic-resistant infections have been steadily increasing since 1990 and are expected to accelerate in the coming decades. Senior author Christopher J.L. Murray called AMR a “big problem” that is here to stay. The study revealed that older adults are particularly vulnerable to these infections, with the number of AMR-related deaths among individuals aged 70 and older increasing by over 80% between 1990 and 2021. By 2050, deaths among seniors are expected to double, potentially surpassing those in all other age groups as the global population ages. The study, which analyzed 520 million data points from 204 countries, projected that around 39 million deaths from antibiotic-resistant infections could occur over the next 25 years, averaging about three deaths per minute. Regions like South Asia and sub-Saharan Africa are expected to bear the heaviest burden, with South Asia alone projected to account for 11.8 million deaths. Lead author Kevin Ikuta highlighted the role of antibiotic overuse and misuse in driving bacterial resistance. He emphasized the importance of better antibiotic stewardship to balance access to life-saving antibiotics while preventing their overuse. Experts like Ishani Ganguli from Harvard Medical School also stressed the need for reducing unnecessary antibiotic prescriptions, particularly for viral infections. The study calls for urgent global action to combat antibiotic resistance by improving infection prevention, promoting responsible antibiotic use, and developing new treatment options. Without these steps, the world faces a growing public health threat that could jeopardize common medical procedures and treatments. Source: NDTV

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