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IIT Madras Releases ‘Bharat Cancer Genome Atlas’ to Advance Cancer Research

IIT Madras has announced the release of the Bharat Cancer Genome Atlas (BCGA), a comprehensive database aimed at bridging the genomic gap in cancer studies. The initiative focuses on improving early detection, treatment strategies, and drug development for Indian breast cancer patients. The project, undertaken in collaboration with Karkinos Healthcare, Chennai Breast Clinic, and Cancer Research and Relief Trust, has successfully sequenced 960 whole exomes from 480 breast cancer patient tissue samples collected from across the country. The resulting database is now publicly accessible to researchers and clinicians at bcga.iitm.ac.in. Key Highlights of the Initiative Rising Cancer Burden: According to the Indian Council of Medical Research (ICMR), one in nine Indians is likely to develop cancer in their lifetime, with a 12.8 percent annual increase in cases since 2022. Lack of Representation in Global Research: India has historically been underrepresented in global cancer genome studies, making it difficult for diagnostic tools and treatments to be tailored to Indian patients. First-of-its-Kind Indian Breast Cancer Genome Database: The BCGA provides a crucial repository of genetic variants specific to Indian breast cancer cases, addressing a long-standing gap in cancer genomics. Prof. V. Kamakoti, Director of IIT Madras, stated that the initiative aligns with the institution’s commitment to societal impact. “By releasing this data, we hope to provide critical insights into the genetic factors contributing to cancer, enabling early intervention and more effective treatments. This dataset fills a major gap in India’s genomic research and offers new possibilities for precision medicine.” How BCGA Will Contribute to Cancer Research and Treatment Early Detection: Identification of cancer-specific biomarkers to improve early diagnosis. Personalized Medicine: Facilitating treatments tailored to genetic and molecular profiles. Improved Treatment Strategies: Enabling the development of novel drug targets. Collaborative Research: Providing an open-access platform for researchers to contribute and analyze data. The project was led by the Centre of Excellence on Cancer Genomics and Molecular Therapeutics at IIT Madras, under the Government of India’s ‘Institutions of Eminence’ initiative. The research was also supported by the Department of Science and Technology, Ministry of Science and Technology, Government of India. Prof. S. Mahalingam, Project Coordinator, emphasized the significance of BCGA, stating: “This database will be an invaluable resource for identifying high-risk groups, monitoring cancer progression, and advancing precision oncology in India. It will also serve as a foundation for developing better treatment strategies specific to the Indian population.” The BCGA is part of a broader effort under the National Center for Precision Medicine in Cancer, a joint initiative between IIT Madras and Karkinos Healthcare aimed at fostering interdisciplinary research for affordable cancer care solutions. With World Cancer Day being observed on February 4, 2025, the release of the BCGA marks a major milestone in India’s cancer research landscape, reinforcing the country’s commitment to advancing precision medicine and improving patient outcomes. Source: iitm. ac

WHO Recommends Potassium-Enriched Salt Substitutes for Better Heart Health

The World Health Organization (WHO) has recommended replacing regular table salt with potassium-enriched, lower-sodium salt substitutes to combat hypertension and cardiovascular diseases. The George Institute for Global Health India has strongly endorsed this initiative, emphasizing its potential to save lives, particularly in countries like India, where high sodium intake and low potassium consumption contribute to widespread health issues. A study conducted by The George Institute for Global Health India, in collaboration with PGIMER Chandigarh, highlights the urgent need for dietary changes in India. It found that salt consumption is significantly above recommended levels, while potassium intake remains insufficient, fueling hypertension, cardiovascular disease, and chronic kidney disease. This research is part of a larger effort to understand how India’s dietary habits are linked to non-communicable diseases (NCDs). Prof. Vivekanand Jha, Executive Director of The George Institute for Global Health India, stated, “To tackle hypertension and heart and kidney disease, especially in rural areas, we must make low-sodium, potassium-enriched salts affordable and accessible. By working with policymakers and the food industry, and educating the public with clear labeling and subsidies, we can save lives and promote a healthier future.” He also emphasized the importance of ensuring the safety and efficacy of salt substitutes, particularly for people with kidney disease. The Salt Substitute in India Study (SSiIS) examined the impact of reduced-sodium, potassium-enriched salt substitutes on blood pressure in rural hypertensive patients. Initial data from the study showed excessive sodium intake, with urinary salt excretion levels at 10.4 g/day—more than double the WHO’s recommended intake. The study found that using salt substitutes was an effective and cost-efficient method to manage hypertension, particularly in high-risk populations. The study, led by Sudhir Raj Thout, Research Fellow at The George Institute for Global Health India, involved 502 hypertensive participants from rural India. Results showed that participants using the reduced-sodium, potassium-enriched salt substitutes for three months experienced notable reductions in both systolic (4.6 mmHg) and diastolic (1.1 mmHg) blood pressure. Additionally, urinary potassium levels and the sodium-to-potassium ratio improved. Participants also found the taste of the substitutes acceptable. Sudhir Raj Thout added, “The WHO’s guidance on lower-sodium salt substitutes is crucial for India, as it offers a simple and affordable solution to lower blood pressure and reduce cardiovascular risks amid the current high levels of sodium intake.” Global and Indian research supports the benefits of potassium-enriched salt substitutes in reducing blood pressure without compromising taste. These substitutes offer a cost-effective and accessible intervention, though individuals with advanced kidney disease should avoid them. The George Institute for Global Health India continues to advocate for potassium-enriched salts, collaborating with policymakers, healthcare providers, and the food industry to promote healthier dietary habits. Source: Express healthcare Photo Credit: Express healthcare

Maharashtra Ministers Highlight Key Initiatives on Republic Day

Health Minister and Kolhapur’s Guardian Minister, Prakash Abitkar, distributed six ambulances for primary health centers and three vaccine vans to enhance healthcare services in Kolhapur and Sindhudurg districts. Abitkar emphasized the need for public awareness to combat misinformation and fear surrounding diseases, urging media platforms to spread accurate information. He also called for the proper maintenance of these vehicles to ensure timely healthcare access, particularly for mothers and children in remote areas. Sangli Encourages Women Entrepreneurs Sangli’s Guardian Minister, Chandrakant Patil, supported women-led self-help groups (SHGs) by purchasing items worth Rs75,000 from 75 stalls at an exhibition held alongside the Republic Day parade. Patil announced that these items would be donated to children in observation homes, showcasing a commitment to empowering women entrepreneurs and supporting social welfare initiatives. Satara Leads in Development with Rs153 Crore Allocation State Tourism Minister and Satara’s Guardian Minister, Shamburaj Desai, unveiled ambitious plans to boost tourism in Satara, including water sports at Munavale, Koynanagar, and Rasati, a flower plateau at Kas, and the Sahyadri Tiger Project. Desai highlighted the district’s efficient use of funds, with Rs153 crores allocated through the District Planning Development Plan for innovative schemes such as the Ideal Primary Health Center and “My School, Ideal School.” He assured further funding efforts for 2024-2025 by engaging with the CM and DCMs to accelerate district development. These initiatives underscore Maharashtra’s focus on healthcare, women’s empowerment, and sustainable district development, setting benchmarks for other regions in the state. Source: Times of India

Pune Faces Projected 13% Rise in Dengue Mortality by 2040: Study Warns of Climate Impact

A groundbreaking study titled “Dengue Dynamics, Predictions, and Future Increase under Changing Monsoon Climate in India” projects a 13% rise in dengue-related mortality in Pune by 2040. Conducted by scientists from IITM, Savitribai Phule Pune University, and international collaborators, the study was published in Scientific Reports on January 21. Highlighting the interplay between climate and dengue, the researchers warned that rising temperatures and erratic monsoon patterns could escalate dengue deaths by 25-40% by mid-century (2040–2060). Pune, a known dengue hotspot, is particularly vulnerable due to increasing average temperatures, uneven rainfall distribution, and higher humidity levels. The study revealed that temperatures above 27°C, moderate and evenly distributed rainfall, and humidity levels between 60% and 78% during monsoon significantly drive dengue transmission. Conversely, extreme rainfall exceeding 150 mm in a week can reduce mosquito prevalence by flushing out larvae and eggs. Under fossil fuel emission scenarios, Pune’s temperature is predicted to rise by 1.2–3.5°C by 2100, amplifying conditions favorable to dengue outbreaks. However, researchers emphasize that socio-economic factors, not included in the projections, could also influence future trends. Lead scientist Dr. Roxy Koll from IITM stressed the need for early warning systems based on health and climate data. Using AI/ML models, the team developed a system capable of predicting dengue outbreaks over two months in advance. “Cooperation from health departments is critical for saving lives,” Dr. Koll said. The findings underscore the urgency for region-specific interventions and better health data integration to combat climate-sensitive diseases. Policymakers in high-burden states can utilize this study to allocate resources effectively and mitigate the public health impact of climate change.

Revolutionizing Health at Maha Kumbh: Mobile Cancer Screening for Women

The Maha Kumbh Mela, celebrated as one of the largest religious gatherings in the world, is now a stage for groundbreaking health initiatives. Among these is the introduction of a pink bus, dedicated to breast cancer detection in women. Spearheaded by Kerala’s Math under the guidance of spiritual leader Maa Amritanandamayi, this bus is equipped with mammography facilities aimed at encouraging early diagnosis. “This initiative addresses the hesitancy many women feel about undergoing breast cancer screenings. The Rs. 4-crore facility marks its debut at the Kumbh, having been inaugurated in Faridabad in 2022,” shared Sant Brahmarishi Eknath of Maa Amritanandamayi Math. Complementing this effort, a mobile mini-hospital bus offers services like X-rays, pathology, minor operations, and telemedicine. In collaboration with ISRO, it connects patients to specialized doctors at the main hospital in Faridabad, ensuring expert guidance from a distance. Why Early Detection Matters Breast cancer survival rates are significantly higher when detected early. Smaller tumors are easier to treat, often allowing less invasive procedures and improving outcomes both physically and emotionally. Despite this, many women delay testing due to taboos surrounding breast health and fear of social stigma. Overcoming Barriers Cultural misconceptions about breast cancer often deter women from seeking timely help. Associations of the disease with lifestyle choices or fears of being labeled “incomplete” add emotional weight, leading to late-stage diagnoses. This initiative at the Kumbh aims to break such barriers, offering hope and access to life-saving medical care. By integrating spiritual support with cutting-edge technology, this effort at the Maha Kumbh Mela not only serves women’s health but sets a precedent for future healthcare outreach.

H5N1 Bird Flu Warning: Preparing for a Potential Outbreak in India

H5N1, or Highly Pathogenic Avian Influenza A, is a significant health concern, posing limited risk to humans but a serious threat overall. This highly infectious respiratory virus primarily affects birds but can spread to humans, particularly those in close contact with infected animals. What is H5N1 and How Does It Spread? Bird flu, caused by the H5N1 virus, mainly spreads among birds but can transmit to humans under specific circumstances, such as close contact with infected birds or contaminated environments. Human-to-human transmission is rare. India’s Situation Since its first detection in 2006, H5N1 has resurfaced sporadically in India, with Maharashtra, West Bengal, and Odisha reporting the most cases. Recent incidents, such as the deaths of three tigers and a leopard at a Nagpur rescue center, underscore the virus’s presence. Symptoms and Risks Symptoms can appear within 2-8 days and range from mild (fever, cough) to severe (acute respiratory distress, organ failure). High-risk groups include poultry workers, livestock handlers, and laboratory personnel. Precautions to Stay Safe: Hygiene: Wash hands thoroughly after exposure to animals. Distance: Avoid contact with wild birds or animals. Protective Gear: Use masks and eye protection when handling potentially infected animals. Cook Food Properly: Ensure thorough cooking of poultry and eggs. Avoid Unpasteurized Products: Steer clear of raw dairy products. Expert Insights Dr. Ashok Rattan, a former WHO expert, advises caution but stresses that human transmissions of H5N1 remain rare. Early detection and proactive prevention are key to reducing risks. While there is no immediate cause for panic, awareness and preventive measures are critical. Breaking the chain of transmission can mitigate the risk of H5N1 escalating into an epidemic or pandemic. Stay informed, cautious, and prepared to ensure public health safety.

AllerVie Health Announces Advisory Council and Welcomes Dr. Ruchi Gupta to Board of Directors

AllerVie Health, a prominent provider of allergy and immunology services across the United States, has taken a significant step to enhance patient care and drive clinical innovation. The organization announced the formation of the AllerVie Advisory Council (AAC) and the addition of Dr. Ruchi Gupta, a globally recognized expert in food allergy and asthma research, to its Board of Directors. The newly established Advisory Council is a clinician-led initiative designed to offer critical insights into clinical practices, operational projects, and patient care protocols. According to Tae Kim, CEO of AllerVie Health and Chair of the AllerVie Advisory Council, this move underscores the company’s commitment to delivering high-quality, accessible care. “The AllerVie Advisory Council is a critical step forward for our company. This council brings together a talented group of clinical leaders whose combined experience and expertise will help us better serve our patients and strengthen our internal culture,” said Kim. “We’re also excited to welcome Dr. Ruchi Gupta to our Board of Directors. Her wealth of knowledge and groundbreaking research in allergy and asthma will be a tremendous asset as we work to provide even better care for our patients.” Key Objectives of the AllerVie Advisory Council: Advise and Endorse: Offer feedback on clinical programs, tools, and processes. Review and endorse initiatives to align with provider and patient needs. Develop Best Practices: Formalize practices in referral engagement, diagnostics, patient experience, compliance, and billing to ensure consistent, high-quality care delivery. Advisory Council Members: Provider Members Dr. Weily Soong | Birmingham, Alabama Dr. Paul Keiser | Alexandria & Falls Church, Virginia | Chambersburg, Pennsylvania Dr. Ashish Mathur | Cincinnati, Ohio Dr. Reena Patel | Hoover, Alabama Dr. Julia Sohn | Washington, D.C. | Germantown, Maryland Dr. Maxcie Sikora | Destin & Panama City, Florida Heather Morris, APRN, NP-C | Lubbock, Texas Corporate Members Tae Kim, CEO and Chair Rachel Russell, Chief Experience Officer Jessica Vogt, Chief Financial Officer Ross Boatwright, Vice President of Strategy and Integrations James Calderwood, Vice President of Operations Taylor Knutson, Council Secretary Dr. Ruchi Gupta Joins the Board of Directors Dr. Gupta brings over two decades of expertise as a pediatrician, researcher, and founding director of the Center for Food Allergy & Asthma Research (CFAAR). She has authored over 200 publications and is renowned for her contributions to food allergy and asthma epidemiology. Her involvement will amplify AllerVie Health’s impact on advancing allergy care nationwide. About AllerVie Health AllerVie Health is a national network of board-certified allergists and immunologists operating in nearly 80 clinics across 13 states. Dedicated to clinical excellence and innovation, AllerVie focuses on improving patient outcomes, expanding access to care, and developing advanced treatments for allergy and immunology. One Mission. One Purpose. One Team. Together, AllerVie Health strives to empower patients to reclaim their lives and live with renewed vitality. Source: Business Wire Photo Credit: Business Wire

China Reports Decline in HMPV Cases Amid Global Watch

Decline in HMPV Infections in China Chinese health officials report a decline in human metapneumovirus (HMPV) cases in northern provinces, alleviating fears of a potential pandemic. Wang Liping, a representative from the Chinese Center for Disease Control and Prevention, stated that positive cases among children under 14 have started to decrease. This update comes as images circulating online suggested overcrowded hospitals in the region, a claim countered by officials citing no significant shortage of medical resources. Gao Xinqiang of the Health Commission clarified that rising patient numbers in fever clinics reflect improved detection methods rather than an actual surge in infections. WHO Monitoring Global HMPV Trends The World Health Organization (WHO) confirmed that no reports of unusual HMPV outbreaks have been received globally, ensuring that monitoring efforts remain intact. India Prepares for Potential Outbreaks India has reported 17 HMPV cases across several states, including Gujarat (5 cases), Maharashtra and West Bengal (3 cases each), Karnataka and Tamil Nadu (2 cases each), and Assam and Puducherry (1 case each). Health authorities in India emphasize that there is no immediate cause for concern but are preparing for potential outbreaks. About HMPV HMPV, related to the respiratory syncytial virus, typically causes mild cold-like symptoms but can lead to severe respiratory infections in vulnerable populations, such as young children, the elderly, and those with weakened immune systems. Key Challenges: No Vaccines or Specific Treatments: Currently, there are no vaccines or targeted treatments available for HMPV. Global Vigilance Required: Improved detection methods help track the virus but emphasize the need for global preparedness. This developing story highlights the importance of proactive monitoring and readiness in addressing emerging health concerns. Source: newsbytesapp Photo Credit : newsbytesapp

Prashant Kishor Hospitalized After Hunger Strike, Admitted to ICU

Prashant Kishor, founder of the Jan Suraaj Party, was admitted to the Intensive Care Unit (ICU) at Medanta Hospital in Patna on Tuesday after suffering from dehydration and an infection. According to sources from his party, Kishor was hospitalized in the morning due to his deteriorating health, which had worsened after days of fasting. The attending physician shared that Kishor’s condition required further examination, citing concerns over infection, dehydration, and overall weakness. “He is also feeling discomfort,” the doctor added. Despite his health struggles, Kishor had earlier told journalists, “My fast unto death will continue,” affirming his commitment to the cause. Kishor’s hunger strike, which began on January 2, was in support of Bihar Public Service Commission (BPSC) aspirants who are protesting the alleged leakage of question papers in the December 2024 BPSC examinations. On Monday morning, authorities detained Kishor following an FIR filed in connection with his ‘fast unto death’ protest at Gandhi Maidan, which violated a Patna High Court directive restricting such protests to the Gardani Bagh area. Kishor was later granted unconditional bail. The protest is part of Kishor’s support for civil service candidates demanding the annulment of the BPSC exams, citing the question paper leak. His ongoing hunger strike has now taken a toll on his health, leading to his hospitalization. Source: Economic Times Photo Credit: Economic Times

HMPV Alert: States Intensify Monitoring as First Cases Reported in Bengaluru

India has reported its first two cases of Human Metapneumovirus (HMPV) in Bengaluru, prompting several states, including Delhi, Maharashtra, and Telangana, to issue health advisories and strengthen surveillance measures. The cases involve two infants—a three-month-old who has been discharged and an eight-month-old currently under treatment. Neither child has a history of international travel, indicating local transmission. HMPV, a respiratory virus similar to the common cold, poses significant risks to vulnerable groups such as infants, the elderly, and those with compromised immune systems. Severe cases can lead to pneumonia or exacerbate pre-existing respiratory conditions. State-Wise Response and Precautions: Delhi: Health authorities have issued guidelines emphasizing reporting Influenza-like Illness (ILI) and Severe Acute Respiratory Infection (SARI) cases through the Integrated Health Information Platform (IHIP). Hospitals are urged to implement strict monitoring and isolation protocols. Maharashtra: The state is enhancing vigilance of SARI and ILI cases, assuring the public that the situation is under control. Kerala: Health Minister Veena George advised high-risk groups, including pregnant women, children, and the elderly, to wear masks and adopt preventive measures. Telangana and Andhra Pradesh: Both states have heightened monitoring and issued public advisories on basic precautions. Andhra Pradesh’s Director of Public Health, Dr. Padmavathi, emphasized the importance of staying informed and adopting simple safety measures. The Union Health Ministry has also reassured citizens there is no cause for panic, urging the public to follow preventive practices similar to those for other respiratory illnesses, such as wearing masks, maintaining hand hygiene, and avoiding crowded spaces. What is HMPV? Human Metapneumovirus (HMPV) is a respiratory virus that spreads through droplets and contact with contaminated surfaces. It commonly causes mild symptoms, including coughing, wheezing, sore throat, and a runny nose. However, in infants, elderly individuals, and immunocompromised patients, the virus can lead to severe complications, such as pneumonia or acute respiratory distress, necessitating immediate medical attention. While unrelated to COVID-19, HMPV shares similar transmission methods and requires preventive measures to curb its spread. With heightened awareness and proactive measures, health authorities aim to mitigate the risks associated with the virus. Source: Business Standard Photo Credit: Business Standard