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Sunday, January 25, 2026 8:29 AM

global health

WHO Report Finds Less Than 5% of Disease-Focused Genomic Studies Conducted in Low- and Middle-Income Countries

A recent global analysis by the World Health Organization (WHO) has revealed a sharp imbalance in disease-focused genomic research, with low- and middle-income countries (LMICs) accounting for less than five per cent of such studies worldwide. According to the WHO, more than 6,500 genomic clinical studies were registered globally between 1990 and 2024 through its International Clinical Trials Registry Platform. The number of studies rose sharply after 2010, driven by rapid advancements in genome sequencing technologies, reduced costs, and expanding clinical applications. Despite this growth, over 80 per cent of genomic research remains concentrated in high-income countries. China emerged as the leading country in terms of the total number of registered genomic clinical studies over the past three decades, followed by the United States and Italy. India ranked among the top 20 countries globally. However, the report noted that LMICs are rarely in leadership roles within such research. India participated in 235 studies, while Egypt, South Africa, and Nigeria featured in 38, 17, and 14 studies respectively—mostly as part of multi-country collaborations rather than as lead partners. The analysis, titled “Human genomics technologies in clinical studies: the research landscape,” highlighted that cancer, rare diseases, and metabolic disorders together account for more than 75 per cent of all genomic studies globally. While these areas were early adopters of genomic approaches, the report flagged a major gap in research on infectious diseases. Communicable diseases such as tuberculosis, HIV, and malaria represented just three per cent of all genomic studies, despite their significant contribution to the global disease burden—particularly in low-resource settings. The authors described this as a missed opportunity to use genomics to better understand disease susceptibility, treatment response, and host–pathogen interactions. The WHO study also pointed to demographic gaps in genomic research. Over three-quarters of studies focused on adults aged 18 to 64, while only 4.6 per cent targeted children and just 3.3 per cent involved older adults. Calling for urgent action, the WHO urged more inclusive, geographically balanced, and locally relevant genomic research. Recommendations included greater investment in genomic infrastructure and research capacity in underrepresented regions, stronger leadership from LMIC-based institutions, better alignment of research priorities with local disease burdens, and increased inclusion of children, older adults, and other underrepresented populations. Source: PTI

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Single HPV Shot Shown to Offer Strong Protection Against Cervical Cancer, Major Study Finds

A landmark international study suggests that one dose of the HPV vaccine may be just as effective as the standard two-dose regimen, potentially transforming cervical cancer prevention efforts worldwide. Researchers announced on Wednesday that a single human papillomavirus (HPV) vaccine shot provided nearly the same level of protection against the virus strains most linked to cervical cancer. HPV is a widespread sexually transmitted infection, and while most cases resolve on their own, persistent infections can lead to cervical cancer and several less common cancers in both women and men. The HPV vaccine has been advised for U.S. girls since 2006, contributing to a decline in precancerous cervical conditions among women in their 20s — the first cohort vaccinated in adolescence. Still, cervical cancer remains a major global threat, causing around 340,000 deaths annually, particularly in parts of the world where vaccination access is limited. The promising findings come from a large Costa Rica-based trial led by the U.S. National Cancer Institute, involving more than 20,000 girls aged 12 to 16. Participants received one of two widely used HPV vaccines. After six months, half received a second dose while the other half were given a different childhood vaccine. Over five years of follow-up, researchers conducted regular cervical screenings and compared results with an unvaccinated control group. Published in the New England Journal of Medicine, the study concluded that a single dose offered about 97% protection, essentially matching the effectiveness of two doses. Dr. Ruanne Barnabas of Massachusetts General Hospital, in an accompanying editorial, highlighted that while earlier studies hinted at single-dose efficacy, this research solidifies long-term confidence in the approach. “We now have the evidence and tools to eliminate cervical cancer — what’s needed is the global commitment to deploy them effectively and fairly,” Barnabas wrote. In the U.S., two doses remain the official recommendation for children aged 11 or 12, with catch-up vaccinations advised up to age 26. The Centers for Disease Control and Prevention reports that 78% of teens aged 13 to 17 have received at least one dose. Worldwide, however, fewer than one-third of adolescent girls are vaccinated, according to the World Health Organization, which has already begun supporting single-dose strategies to improve coverage. Researchers noted that the study did not assess protection against other HPV-related cancers, such as those of the head and neck, and stressed that longer-term monitoring is still necessary. Source: AP

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Kidney Cancer Cases Could Nearly Double Worldwide by 2050: Study

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A new global study warns that kidney cancer cases may almost double over the next quarter century if current health trends continue. Researchers from Europe, the US, and the UK examined data from the Global Cancer Observatory of the International Agency for Research on Cancer, projecting a dramatic surge in both incidence and mortality. In 2022, around 435,000 new cases and 156,000 deaths from kidney cancer were recorded worldwide. By 2050, the figures could rise to nearly 746,000 cases (a 72% increase) and over 304,000 deaths (a 96% rise), according to findings published in European Urology. The rise is linked largely to modifiable risk factors such as obesity, hypertension, diabetes, smoking, and physical inactivity, alongside environmental exposures. While 5–8% of cases are estimated to have a genetic basis, researchers emphasized that more than half of all kidney cancer cases are preventable. “Kidney cancer is becoming a global health challenge. Clinicians and policymakers must brace for this sharp increase,” said senior author Alexander Kutikov, Chair of the Department of Urology at Fox Chase Cancer Center in the US. He noted that lifestyle interventions—including maintaining a healthy weight, controlling blood sugar and blood pressure, and quitting smoking—can substantially reduce risk. The study also revealed wide geographical and gender-based disparities in incidence and survival. Five-year survival rates currently range between 40% and 75%, with wealthier nations expected to benefit from early detection through routine imaging and better access to advanced treatments such as surgery and radiotherapy. The findings add to a broader global concern: a recent Lancet analysis estimated that annual cancer deaths of all types may climb by 75% over the next 25 years. Alarmingly, 40% of these deaths are linked to 44 preventable risk factors, including poor diet, tobacco, and high blood sugar. Source: PTI

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The Changing Face of Health: Why Prevention Matters More Than Cure

Health is no longer just about curing illnesses — it is about building resilience, balance, and longevity. In an age where medical technology is advancing rapidly, one truth stands out: most health challenges of today can be prevented through timely lifestyle choices. From Reactive to Proactive Healthcare Traditionally, healthcare systems have been reactive, stepping in only after illness occurs. But the global rise of non-communicable diseases (NCDs) — such as diabetes, heart disease, respiratory disorders, and cancers — is changing that mindset. According to the World Health Organization (WHO), NCDs account for over 70% of global deaths each year, many of which are linked to modifiable factors like poor diet, sedentary lifestyle, smoking, and stress. Preventive healthcare focuses on early detection, timely intervention, and healthy living habits. Regular health check-ups, vaccinations, screenings, and wellness programs can significantly reduce the burden of disease, not just on individuals but also on healthcare systems. The Mind-Body Connection Health is multidimensional. Beyond physical well-being, mental health is increasingly recognized as a key factor. Stress, depression, and anxiety often manifest in the body as fatigue, poor immunity, or even chronic illness. For example, long-term stress can contribute to hypertension and heart disease. To counter this, practices like yoga, meditation, breathing exercises, and mindfulness are gaining popularity worldwide. Social support systems — family, friends, and community engagement — also play a powerful role in maintaining mental wellness. Nutrition and Lifestyle: The Foundation of Good Health The saying “we are what we eat” has never been truer. Diets rich in whole foods, fresh fruits, vegetables, lean proteins, and healthy fats are proven to reduce the risk of lifestyle-related conditions. On the other hand, excessive consumption of processed foods, sugar, and unhealthy fats is directly linked to obesity and metabolic disorders. Equally important is physical activity. Experts recommend at least 150 minutes of moderate exercise per week, which could be as simple as brisk walking, cycling, or swimming. Combined with quality sleep and adequate hydration, these habits form the foundation of long-term health. Technology: A Game-Changer in Healthcare Digital health tools are reshaping the way people monitor and manage their well-being. Wearable devices can track heart rate, sleep quality, and physical activity, while telemedicine platforms make healthcare accessible from home. Artificial intelligence (AI) is being used to detect early signs of diseases through scans and lab data, helping doctors make faster and more accurate diagnoses. This patient-centric approach empowers individuals to take control of their health, reducing dependency on hospitals for routine care. Community and Policy Initiatives Health is not just personal — it is social. Governments, workplaces, and schools are increasingly adopting wellness programs, from fitness incentives to mental health counseling. Public awareness campaigns on vaccination, hygiene, and balanced diets continue to play a pivotal role in improving community health standards. Policies that encourage pollution control, clean water, urban green spaces, and accessible healthcare facilities further strengthen the foundation of healthier societies. Building a Healthier Future The future of healthcare lies in a holistic model — where physical, mental, social, and environmental health are interconnected. Instead of waiting for illness to strike, people and systems must embrace prevention as the core of well-being. By making conscious choices — nutritious eating, regular exercise, stress management, technology-driven monitoring, and preventive check-ups — individuals can not only add years to life but also life to years. As the adage goes, “Health is wealth.” In the 21st century, that wealth depends on how well we balance innovation, awareness, and proactive living.

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Breakthrough in Understanding Childhood Immunity to Strep A Could Accelerate Vaccine Development

A team of scientists has uncovered how young children naturally build immunity against Group A Streptococcus (Strep A), a bacterial infection responsible for up to half a million deaths worldwide each year. The finding could significantly speed up the creation of a life-saving vaccine. Strep A is a common bacterium that can cause mild illnesses like sore throat and skin infections, but in severe cases, it can trigger life-threatening diseases. While deaths from Strep A are rare in wealthier nations, outbreaks can be devastating. In late 2022, a surge in cases across the UK and Europe claimed hundreds of lives, including those of many children. The burden is far greater in low- and middle-income countries, where thousands die annually from the infection. Researchers from the University of Sheffield, working with the Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine, tracked how Gambian children acquire natural immunity. Published in Nature Medicine, the study identified specific antibodies linked to protection from Strep A, marking a crucial step toward vaccine design. The team observed that babies are born with some immunity passed down from their mothers, but this protection fades quickly. Young children, however, develop robust antibody responses to different components of the bacteria after repeated exposure. This discovery pinpoints a key window for immune development, which could guide more effective vaccination strategies. Lead researcher Dr. Alex Keeley said this is the first time scientists have seen in humans how antibodies generated through vaccination might prevent Strep A infections. Gambian scientist Fatouamta Camara described the infection’s “devastating burden” on communities and expressed hope that a vaccine could break the cycle of illness and socio-economic hardship. The research was a collaboration between Sheffield’s Florey Institute of Infection and the GSK Vaccine Institute for Global Health. Professor Thushan de Silva, who co-directed the study, emphasised the importance of cross-institutional efforts in delivering impactful global health research. Source: PTI

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WHO Urges Boost in TB Research and Innovation to Tackle High Burden in South-East Asia

The World Health Organization (WHO) has issued an urgent call to enhance research, innovation, and regional cooperation to eliminate tuberculosis (TB) in the South-East Asia region — a region that continues to carry nearly half of the global TB burden. Speaking at the launch of a three-day virtual workshop focused on advancing TB research and innovation, Dr. Catharina Boehme, Officer-in-Charge for WHO South-East Asia, emphasized that in 2023 alone, the region saw nearly 5 million new TB cases and around 600,000 related deaths. The workshop brings together national TB programme leaders, scientists, civil society members, and global partners to push forward efforts aligned with the WHO’s End TB Strategy. The Need for Urgency and Collaboration Dr. Boehme highlighted that ending TB demands the rapid adoption of new tools, diagnostics, and treatments — and, more importantly, equitable and timely access to these innovations. “Collaboration is key to scaling up impact and ensuring that no one is left behind,” she stated. Despite a post-COVID-19 rebound in TB case detection in 2023, current progress is falling short of the End TB Strategy’s 2030 goals: a 90% drop in TB-related deaths and an 80% decline in incidence compared to 2015. Alarmingly, TB has returned as the world’s leading cause of death from a single infectious disease, with its effects disproportionately hitting the poorest and most vulnerable communities. In South-East Asia, between 30% and 80% of TB-affected households experience catastrophic healthcare expenses, pointing to the urgent need for inclusive, people-first approaches and stronger social protection systems. Signs of Progress Amidst Challenges Still, there are signs of advancement. In 2023, the region recorded 3.8 million new or relapsed TB cases, with an 89% treatment success rate among those who began treatment in 2022. The number of undiagnosed cases was significantly reduced — down to 22% from 44% in 2020. Countries are increasingly adopting technology-driven solutions such as artificial intelligence for detecting TB, digital adherence tools to monitor treatment, and direct benefit transfers to ease patients’ financial burdens. These innovations are being powered by strong political will and national commitment. Several countries have also expanded research efforts. Bangladesh has concluded a national patient cost survey, while India’s RATIONS study provided valuable insights on the role of nutrition in TB prevention and recovery. Nepal’s “TB-Free Pallika” initiative and Myanmar’s multisectoral coordination model are examples of community-led innovations that prioritize vulnerable populations. According to WHO, over 3,000 TB-related research papers were published by South-East Asian countries in the past six years, with 60% being original research. However, the challenge lies in transforming these findings into action, as knowledge gaps and lack of collaborative platforms hinder broader impact. Strengthening Regional and Global Coordination The workshop will also focus on building stronger South-South collaboration, vaccine readiness, use of digital tools for patient care, and tackling vaccine hesitancy. Discussions will revolve around aligning regulatory frameworks, improving knowledge-sharing platforms, and setting research priorities that address underlying drivers of TB — such as malnutrition and climate-related risks. Dr. Boehme noted the growing threat posed by drug-resistant TB and emphasized the importance of ensuring that scientific progress benefits everyone equally. “Access to new vaccines, medicines, and diagnostics must be equitable. Reaching underserved communities through proactive case-finding and offering socio-economic support is essential in mitigating the financial toll of TB,” she concluded. Source: PTI Photo Credit: Getty Images

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India May Face Over 1.6 Million Gastric Cancer Cases, Global Study Warns

A new international study published in Nature Medicine has sounded the alarm over a possible surge in gastric cancer cases, predicting that more than 15 million individuals born between 2008 and 2017 could develop the disease globally during their lifetime. India is projected to bear a significant burden, second only to China, with an estimated 1.6 million cases if current prevention efforts remain unchanged. The research, led by the International Agency for Research on Cancer (IARC), the cancer research wing of the World Health Organization, used global cancer incidence data from GLOBOCAN 2022 along with UN demographic forecasts. It found that nearly two-thirds of future gastric cancer cases will likely emerge in Asia, with India and China alone expected to contribute about 6.5 million new diagnoses. A key finding of the study highlights that 76% of these cases could be linked to Helicobacter pylori—a widespread and chronic bacterial infection of the stomach that significantly increases cancer risk. Despite being preventable and treatable, H. pylori remains a major health challenge in many countries. Gastric cancer is currently the fifth most deadly cancer worldwide. The study also points to an anticipated six-fold rise in cases across sub-Saharan Africa, where the current incidence is relatively low. Experts behind the research are urging governments to invest in large-scale preventive measures—especially in screening and treatment programs targeting H. pylori. They stress that such interventions could slash future cancer cases by as much as 75%. The researchers warn that an ageing global population, along with rising cancer rates in younger people, could undo recent progress in cancer control if swift action is not taken. The findings reinforce the urgent need for countries, particularly in Asia, to enhance public health strategies focusing on early diagnosis, education, and bacterial eradication to curb the looming threat of gastric cancer. Source: CNBCTV18

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Highly Contagious COVID-19 Variant NB.1.8.1 Spreads from China to the US

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A newly emerging COVID-19 variant, NB.1.8.1 — known for its high transmissibility and recent surge in China — has now been identified in the United States, including cases in New York City, according to the Centers for Disease Control and Prevention (CDC). The variant was first detected among international travelers entering the U.S. between late March and early April through airports in California, Washington State, Virginia, and New York. Since then, additional infections have been reported in Ohio, Rhode Island, and Hawaii. Although the U.S. case count remains relatively small, public health experts are monitoring the situation closely due to the variant’s rapid spread across Asia, where it has become the leading strain. In Hong Kong, the NB.1.8.1 variant has led to a significant rise in hospital admissions and emergency visits, particularly affecting senior citizens. Reports indicate that within a span of four weeks, the city recorded 81 severe cases and 30 fatalities, primarily among individuals aged 65 and older. Mainland China has also seen a steep increase in COVID-positive patients in emergency departments, along with a spike in hospitalizations. However, Chinese health authorities maintain that the variant does not pose a greater threat than earlier strains. U.S. experts are taking a more cautious stance. Dr. Amy Edwards of Case Western Reserve University noted that while NB.1.8.1 may not result in more severe illness, its rapid transmission is concerning. “There’s a clear increase in hospital activity in places like China and Hong Kong,” she told CBS News. CDC data shows that those carrying the variant had traveled from countries including China, Japan, South Korea, Vietnam, Thailand, France, Spain, and Taiwan — suggesting broader international transmission. NB.1.8.1 presents symptoms similar to prior variants — including fatigue, fever, sore throat, and coughing — but scientists believe it has a “growth advantage,” potentially allowing it to spread more efficiently. Dr. Subhash Verma from the University of Nevada highlighted this increased transmissibility as a cause for concern. In Hong Kong, Dr. Edwin Tsui of the Centre for Health Protection urged vigilance, warning that the variant might be more adept at bypassing existing vaccine defenses. Health officials there are tracking the variant’s evolution in line with World Health Organization (WHO) guidance. The emergence of NB.1.8.1 coincides with changes to U.S. COVID-19 vaccine policy. The CDC recently updated its guidelines, advising against routine vaccination for healthy children and pregnant women. Future booster shots will primarily target high-risk populations, such as the elderly and immunocompromised individuals. Source: NDTV Photo Credit: Reuters

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India Joins Global Pandemic Treaty; PM Emphasizes Role of Global South in World Health

In a landmark step towards bolstering global health security and future pandemic preparedness, India has officially joined other WHO member nations in endorsing the Pandemic Treaty during the 78th World Health Assembly held in Geneva. Addressing the assembly, the Prime Minister highlighted the critical need for inclusive global healthcare, stating, “The future of a healthy world depends on inclusion, and the health of the world depends on how well we care for the most vulnerable, especially in the Global South who are particularly impacted by health challenges.” He also drew attention to India’s domestic strides in public health, mentioning that government health spending has surged while citizens’ out-of-pocket medical costs have declined significantly. He credited this progress to flagship initiatives such as Ayushman Bharat, which extends free healthcare coverage to over 580 million people, and to the proliferation of affordable public pharmacies. “India has established a vast network of Health and Wellness Centres (HWC) that offer screening for major conditions such as cancer, diabetes, and hypertension. India’s digital platform to track vaccination of pregnant women and children is helping to integrate benefits, insurance, records, and information,” the Prime Minister said. The assembly’s primary goal this year was the finalization of the Global Pandemic Treaty, and the Prime Minister commended the efforts of the WHO and all negotiating nations. “India’s initiatives have brought down out-of-pocket expenditure as a percentage of total health expenditure significantly, while government health expenditure has increased considerably,” he added. A WHO statement confirmed the treaty’s adoption during a plenary session of the assembly, which serves as the organization’s highest decision-making body. The treaty was approved by vote in committee, with 124 nations in favor and 11 abstaining. No country formally opposed the agreement. The Pandemic Agreement outlines key principles and strategies to enhance international collaboration in areas like vaccine access, diagnostics, and treatment distribution, all aimed at reinforcing global preparedness and response to health emergencies. However, the agreement was adopted without participation from the United States, a major WHO donor, which had previously halted its funding commitments to the organization earlier this year. Source: Economic Times  

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WHO Prepares for Life After U.S. Exit Amid Deep Budget Cuts and Donor Shift

As the World Health Organization (WHO) prepares for its annual assembly in Geneva starting May 19, a significant shift looms over the global health body: how to navigate a future without its top financial backer, the United States. The week-long gathering, typically a forum for setting health priorities and policy, approving vaccines, and coordinating international disease responses, is this year overshadowed by the U.S. decision to leave the organization. In January, President Donald Trump issued an executive order initiating the year-long withdrawal process on his first day back in office. With the U.S. accounting for roughly 18% of the WHO’s funding, officials are now grappling with how to stretch limited resources. “Our goal is to focus on the high-value stuff,” said Daniel Thornton, WHO’s director of coordinated resource mobilisation. While specifics remain under discussion, internal planning documents seen by Reuters suggest the agency will prioritize its emergency response and medicine approval efforts, while scaling back on training programs and potentially closing offices in high-income countries. Key health guidance on vaccines and diseases such as HIV and obesity is expected to continue. A Western diplomat, speaking anonymously, acknowledged the challenge ahead: “We’ve got to make do with what we have.” WHO staff have already begun budget and personnel cuts in anticipation of the funding shortfall. Though the U.S. remains a member until January 21, 2026, under the legally mandated transition period, signs of a policy reversal are slim. President Trump initially left the door open to rejoining if the organization “clean it up,” but health envoys say no concrete steps have followed. In the meantime, WHO faces an immediate budget gap of $600 million this year, with deeper cuts—up to 21%—expected over the next two years. As the U.S. steps back, China is poised to become the largest contributor of assessed contributions—one of WHO’s key funding streams. China’s share will rise from over 15% to 20% following a 2022 funding restructure. “We have to adapt ourselves to multilateral organisations without the Americans. Life goes on,” said Chen Xu, China’s ambassador to Geneva. The evolving donor landscape has prompted calls for deeper reform. Anil Soni, CEO of the WHO Foundation, questioned whether the organization still needs its vast array of committees or to publish thousands of documents each year. He added that the transition was forcing a reassessment of operations, including whether WHO should handle routine logistics like fuel purchases during crises. Soni emphasized the urgency of sustaining vital programs amid the funding squeeze, noting that the agency is increasingly turning to philanthropies and the private sector for targeted support. The ELMA Foundation, for instance, recently contributed $2 million to support the Global Measles and Rubella Laboratory Network, which includes over 700 labs monitoring infectious disease threats. Alongside pandemic preparedness agreements and an investment round to court new donors, funding will remain the central concern at the Geneva meeting. A WHO manager’s recent request for staff to volunteer as ushers—without extra pay—reflects the broader austerity mindset taking hold. Source: Reuters Photo Credit: Reuters

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