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global health

Three Million Child Deaths Linked to Drug Resistance: A Global Health Crisis

A recent global study has sounded alarm bells over the escalating threat of antimicrobial resistance (AMR), revealing that 3 million child deaths in 2022 were linked to infections no longer responding to standard antibiotics. The report, compiled by the Murdoch Children’s Research Institute (Australia) and the Clinton Health Access Initiative, highlights how AMR is fast becoming a global health crisis—particularly affecting children in Africa and Southeast Asia. AMR occurs when bacteria, viruses, or fungi evolve to resist the effects of medicines that once worked against them. As a result, common infections become harder—and sometimes impossible—to treat. This “silent pandemic” has been aggravated by the overuse and misuse of antibiotics, especially in countries like India, which has been flagged as a hotspot due to regulatory gaps and easy access to drugs. Key findings include: 3 million global child deaths in 2022 were AMR-related. 752,000 child deaths occurred in Southeast Asia, and 659,000 in Africa. Use of ‘watch antibiotics’ (for serious infections) rose by 126% in Africa and 160% in Southeast Asia from 2019 to 2021. Use of ‘reserve antibiotics’ (last-resort drugs) increased by 125% and 45%, respectively. The study attributes the rise to overcrowded hospitals, poor sanitation, lack of diagnostic access, and weak antimicrobial stewardship. It also underscores the slow pace of new antibiotic development, which further reduces treatment options for resistant infections. Experts recommend a “One Health” approach, integrating data on how infections spread among humans, animals, and the environment. They also urge stronger national policies, hospital-level antibiotic regulation, and the use of real-time health data to guide responsible treatment decisions. With the World Health Organization already warning about AMR’s impact on mortality and health systems, the report stresses that immediate action is critical to prevent a catastrophic rise in untreatable infections among the most vulnerable—our children. Source: Indiatoday

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Gennova Biopharma Partners with CEPI to Develop mRNA Nipah Vaccine

Gennova Biopharmaceuticals, a subsidiary of Emcure Pharmaceuticals, has announced a partnership with the Coalition for Epidemic Preparedness Innovations (CEPI) to develop a self-amplifying mRNA (saRNA) vaccine for the Nipah virus. The collaboration has secured up to $13.38 million in funding from CEPI to accelerate research and development. Innovative Approach to Vaccine Development As part of this initiative, Gennova will work with the Houston Methodist Research Institute (HMRI), a CEPI partner based in the United States, to integrate artificial intelligence (AI) into vaccine design. AI-driven analysis will be used to identify optimal vaccine targets, enhancing immune response efficiency. Clinical trials are set to begin in India, where Nipah outbreaks have previously occurred. The Nipah Virus Threat Nipah virus, a highly lethal pathogen from the Paramyxovirus family, has caused multiple outbreaks in South and Southeast Asia, with a fatality rate of up to 75%. Though outbreaks have been geographically limited, the virus’s natural reservoir—fruit bats—inhabits regions home to over two billion people, making it a serious global health concern. CEPI’s Commitment to Global Health Kent Kester, Executive Director of Vaccine R&D at CEPI, emphasized the urgency of the project, stating: “With no approved vaccines or specific treatments for Nipah, CEPI is leading the global effort to develop countermeasures. Gennova’s saRNA technology could not only help fight Nipah but also enhance pandemic preparedness, enabling rapid responses within 100 days of identifying a new viral threat.” The Advantage of saRNA Vaccines Unlike traditional mRNA vaccines, which introduce pre-made antigenic proteins, saRNA vaccines provide genetic instructions that enable the body’s own cells to produce these proteins. This approach enhances the immune response while requiring lower doses, making it a promising platform for future vaccine development. A Long-Term Collaboration Gennova’s partnership with CEPI is not new. In August 2023, CEPI granted the company $3.6 million to optimize its saRNA technology for developing vaccines against unknown pathogenic threats, often referred to as Disease X. Sanjay Singh, CEO of Gennova Biopharmaceuticals, commented on the collaboration: “By harnessing our saRNA platform, we aim to develop a next-generation Nipah vaccine. This partnership sets a new benchmark for rapid vaccine development while ensuring equitable access and strengthening global health security.” Ensuring Equitable Access CEPI has invested over $100 million in Nipah vaccine research. Through this collaboration, Gennova has pledged to uphold CEPI’s Equitable Access Policy, ensuring that the vaccine, if successfully developed, will be made available first to at-risk populations at an affordable price. The agreement also includes provisions for technology transfer, which could support future vaccine development efforts against emerging infectious diseases.

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China Reports Decline in HMPV Cases Amid Global Watch

Decline in HMPV Infections in China Chinese health officials report a decline in human metapneumovirus (HMPV) cases in northern provinces, alleviating fears of a potential pandemic. Wang Liping, a representative from the Chinese Center for Disease Control and Prevention, stated that positive cases among children under 14 have started to decrease. This update comes as images circulating online suggested overcrowded hospitals in the region, a claim countered by officials citing no significant shortage of medical resources. Gao Xinqiang of the Health Commission clarified that rising patient numbers in fever clinics reflect improved detection methods rather than an actual surge in infections. WHO Monitoring Global HMPV Trends The World Health Organization (WHO) confirmed that no reports of unusual HMPV outbreaks have been received globally, ensuring that monitoring efforts remain intact. India Prepares for Potential Outbreaks India has reported 17 HMPV cases across several states, including Gujarat (5 cases), Maharashtra and West Bengal (3 cases each), Karnataka and Tamil Nadu (2 cases each), and Assam and Puducherry (1 case each). Health authorities in India emphasize that there is no immediate cause for concern but are preparing for potential outbreaks. About HMPV HMPV, related to the respiratory syncytial virus, typically causes mild cold-like symptoms but can lead to severe respiratory infections in vulnerable populations, such as young children, the elderly, and those with weakened immune systems. Key Challenges: No Vaccines or Specific Treatments: Currently, there are no vaccines or targeted treatments available for HMPV. Global Vigilance Required: Improved detection methods help track the virus but emphasize the need for global preparedness. This developing story highlights the importance of proactive monitoring and readiness in addressing emerging health concerns. Source: newsbytesapp Photo Credit : newsbytesapp

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Over 1 in 5 Adults Worldwide Infected with Genital Herpes: WHO

According to the World Health Organization (WHO), over 846 million people aged 15 to 49, or more than one in five individuals in this age group, are living with genital herpes infections globally. These findings, published in the journal Sexually Transmitted Infections, highlight the widespread nature of the infection and underscore the urgent need for improved prevention, treatment, and vaccine development. Each year, an estimated 42 million people contract a new genital herpes infection, equating to one new case every second. While many infections are asymptomatic, over 200 million individuals in 2020 experienced painful genital sores and blisters, often requiring repeated medical visits. Dr. Meg Doherty, WHO’s Director of Global HIV, Hepatitis, and STI Programmes, emphasized the strain on global health systems: “Genital herpes causes pain and distress for millions, and better prevention and treatment options are critical to controlling its spread and reducing its health impacts, including its link to an increased risk of HIV transmission.” The study estimates 520 million people have genital HSV-2, responsible for 90% of symptomatic cases and associated with a three-fold higher HIV risk. An additional 376 million are infected with genital HSV-1, which is increasingly transmitted during adulthood due to declining childhood oral infections. Herpes infections carry significant social and economic burdens. Stigma often silences discussions about the infection, and healthcare costs and productivity losses are estimated at $35 billion annually. WHO advocates consistent condom use and avoiding sexual contact during active outbreaks to reduce transmission. It also recommends HIV testing for individuals with genital herpes and pre-exposure prophylaxis when needed. Research into vaccines and new treatments remains a priority, as these advancements could significantly improve global health outcomes and reduce the stigma surrounding herpes infections. Source: World Health Organization Photo Credit: World Health Organization

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Ministry of Ayush to Celebrate 9th Ayurveda Day with Focus on Global Health Innovations

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The Ministry of Ayush is set to celebrate the 9th Ayurveda Day on October 29 at the All India Institute of Ayurveda (AIIA) in New Delhi. This year’s theme, Ayurveda Innovations for Global Health, highlights the expanding role of Ayurveda in addressing global health challenges. The event is expected to draw participation from over 150 countries, reflecting Ayurveda’s growing international recognition. Minister of State for Ayush, Prataprao Jadhav, emphasized the significance of Ayurveda Day as a global movement. He noted that this year’s theme underscores the contributions of Ayurveda to global health advancements. The government aims to promote Ayurveda as a robust medical system worldwide, benefiting public health across borders. In discussing the Ministry’s recent initiatives, Jadhav pointed to efforts to make Ayurveda knowledge more accessible to the public through digital platforms under the Ayush Grid. This includes innovative programs such as the Ayurgyan Scheme, the Ayush Research Portal, and the Namaste Portal. He further highlighted that Ayurveda is currently recognized in 24 countries, with Ayurveda products being exported to over 100 nations. The celebration of Ayurveda Day demonstrates the Ministry’s commitment to advancing traditional medicine in a modern context, while promoting holistic well-being and health innovation on a global scale. Source: newsonair. gov

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Melinda French Gates Launches $250 Million Initiative to Address Global Women’s Health Crisis

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Melinda French Gates has unveiled a $250 million global initiative aimed at tackling critical issues in women’s health, including maternal mortality, malnutrition, and access to reproductive healthcare. The initiative, called Action for Women’s Health, seeks to provide funding to organizations addressing these challenges, particularly in underserved communities. The announcement comes amid growing concerns over rising maternal deaths and healthcare deserts, especially following the U.S. Supreme Court’s decision to overturn Roe v Wade in 2022. In an interview with The Guardian, French Gates expressed alarm over the healthcare disparities faced by women worldwide. “More than 700 women die from childbirth every day, and over one billion women and girls suffer from malnutrition. These numbers are unacceptable,” she said. The new initiative invites women’s health-focused organizations globally to apply for grants of up to $5 million to help scale their efforts. French Gates emphasized the urgency of addressing these issues, especially with the upcoming U.S. elections, which she described as pivotal for women’s rights. “There is so much at stake for women and families in this election, and we need a leader who will fight for women’s rights, especially their access to reproductive care,” she stated, publicly endorsing U.S. Vice President Kamala Harris. This initiative is part of a broader $1 billion commitment from French Gates over the next two years to support women’s health and rights globally. She has called on community-driven organizations with proven track records to apply for funding, stressing that women’s health is foundational to the well-being of society as a whole. Source: Business Standard

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WHO and FIND Join Forces to Accelerate Diagnostic Innovation and Access

FIND and the World Health Organization (WHO) have signed a new Memorandum of Understanding (MoU) that lays the foundation for accelerating innovation and achieving equitable access to quality diagnostics for people globally. One year on from the historic resolution to strengthen diagnostics, and with FIND as co-lead of the Access to COVID-19 Tools (ACT) Accelerator diagnostics pillar, this new agreement marks a step change in a strengthened partnership between WHO and FIND to speed up both innovation and access to diagnostics, supporting countries to implement the World Health Assembly (WHA) Resolution on diagnostics. “We are proud to be signing this MoU with WHO, as quality and accessible diagnostic testing is the backbone of health systems, primary healthcare and health security,” said Dr. Ayoade Alakija, Board Chair of FIND. “At a time when there have been three cases of H5N1 avian flu spillover events from cows to humans in the last month and an outbreak of mpox in the Democratic Republic of the Congo, the importance of diagnostic testing to identify outbreaks and quash them before they become major epidemics or even pandemics has never been more critical.” This new agreement establishes FIND as the key strategic partner for diagnostics, working with WHO and others to address a number of priority areas including antimicrobial resistance, infectious diseases like HIV, malaria and tuberculosis, and noncommunicable diseases like hypertension, heart disease, cervical cancer and diabetes. Signed on 1 June 2024 at a ceremony attended by Dr. Tedros Adhanom Ghebreyesus, Dr. Yukiko Nakatani (Assistant Director-General), and Dr. Ayoade Alakija (Board Chair of FIND), the MoU will also see the two organizations building new avenues to share knowledge and scale up critical activities to accelerate access to life-saving diagnostics. The signing of this MoU formalizes a long-standing partnership between WHO and FIND and marks a major milestone in the journey towards better health and well-being across the world. By leveraging the strengths and expertise of both WHO and FIND, this partnership promises to drive innovation on diagnostic tests and also improve access to the tests to reduce health inequalities, ultimately leading to a healthier future for people everywhere.  

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Closing the Women’s Health Gap: A $1 Trillion Opportunity for Global Well-being

Blog on Health

In a study by the McKinsey Health Institute in collaboration with the World Economic Forum (WEF), the report titled “Closing the women’s health gap: A $1 trillion opportunity to improve lives and economies” sheds light on the profound impact of gender disparities in healthcare on both individual well-being and global economic prosperity. The study, focused on addressing the health gap between men and women, reveals startling statistics that demand urgent attention and action. Key Findings: Unraveling the Women’s Health Gap The report brings to light the alarming fact that while women tend to live longer than men, they spend 25 percent more of their lives grappling with poor health. This health disparity translates into a staggering 75 million years of life lost annually due to illnesses or premature death among women. The study identifies key areas contributing to the women’s health gap: Health Conditions Affecting Both Genders: 95 percent of the health burden on women is attributed to conditions affecting both men and women, such as sexual and reproductive health, maternal and child health, and endometriosis. Prevalence of Conditions in Women: 56 percent of the health burden on women arises from conditions that are either more prevalent or manifest differently in women. The Case of India: A $22 Billion Opportunity In the context of India, the study highlights that closing the gender gap in healthcare could lead to a substantial economic boost. The report estimates that India’s GDP could rise by at least $22 billion by addressing the health disparities between men and women. The top health conditions contributing to this potential GDP impact include premenstrual syndrome, gynecological diseases, migraine, depressive disorders, and anxiety disorders. Global Root Causes: Science, Care Delivery, Investment, and Data The report identifies four primary global root causes contributing to the women’s health gap: Science: Historically, the study of human biology has predominantly focused on the male body, leading to less effective treatments for women. Over 50 percent of interventions with sex-disaggregated research are found to be less effective for women than men. Care Delivery: Women often face barriers to care, diagnostic delays, and suboptimal treatment due to healthcare systems designed and run predominantly by men. Investment: There has been lower investment in women’s health conditions relative to their prevalence, perpetuating limited scientific understanding and data on women’s bodies. Data: Health burdens for women are systematically underestimated, with incomplete datasets that exclude or undervalue crucial conditions affecting women. Closing the Gap: A Trillion-Dollar Opportunity The report emphasizes the potential economic and societal benefits of addressing the women’s health gap: Economic Growth: For every $1 invested in women’s health, the projection is nearly $3 in economic growth. Global Impact: Closing the health gap could add 7 more days of healthy living for each woman annually, contribute at least $1 trillion to the global economy by 2040, and generate an impact equivalent to 137 million women accessing full-time positions. Reduced Health Burden: Addressing the gaps in women’s health could reduce the time women spend in poor health by almost two-thirds, positively impacting 3.9 billion women. Strategies for Change To achieve health equity and foster economic growth, the report suggests a comprehensive strategy involving various stakeholders: Invest in Research: Prioritize women-centric research to fill knowledge and data gaps in women-specific conditions. Data Collection: Systematically collect and analyze sex-, ethnicity-, and gender-specific data for accurate representation of women’s health burden. Enhance Access: Improve access to gender-specific care, from prevention to diagnosis and treatment. Financing Models: Incentivize new financing models to support women’s health initiatives. Business Policies: Establish business policies that actively support women’s health. Raise Awareness: Promote awareness and advocacy to draw attention to the women’s health gap. By prioritizing women’s health in research, care, and investment, societies can unlock immense economic potential while ensuring a healthier

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India Leads Global Preterm Births in 2020, Lancet Study Reveals

In 2020, India witnessed the highest number of preterm births globally, with a staggering 3.02 million cases, constituting over 20 percent of all premature births worldwide, as revealed by a study published in The Lancet journal. This research, conducted by experts from the World Health Organization (WHO), the United Nations Children’s Fund (UNICEF), and the London School of Hygiene and Tropical Medicine, UK, further disclosed that more than half of all premature births in 2020 occurred in just eight countries. Following India, the countries with the highest preterm birth rates were Pakistan, Nigeria, China, Ethiopia, Bangladesh, the Democratic Republic of the Congo, and the United States, according to the researchers. The notable prevalence of preterm births in these regions is partly attributable to their substantial population sizes, high numbers of total births, and underdeveloped healthcare systems that struggle to provide high-quality family planning, antenatal care, and childbirth services to all those in need. Globally, approximately 13.4 million babies were born prematurely in 2020, with nearly one million succumbing to complications associated with preterm birth. This data equates to roughly one in ten babies being born prematurely, before completing 37 weeks of pregnancy worldwide. Given that prematurity ranks as the leading cause of child mortality in their early years, there is an urgent need to bolster both preterm infant care and preventative measures, particularly focusing on maternal health and nutrition to enhance child survival, emphasize the authors of the study. Furthermore, preterm birth significantly increases the likelihood of major illnesses, disabilities, developmental delays, and even chronic diseases like diabetes and heart conditions in adulthood for those who survive. This study derives its estimates from data that is representative of populations and national statistics, enabling internationally comparable assessments for the year 2020. It highlighted that India had the highest incidence of preterm births in 2020, totalling 3.02 million cases, accounting for over a fifth of all preterm births worldwide. While most high preterm birth rates were observed in low and middle-income nations, rates of 10 percent or higher were also evident in high-income countries such as Greece and the United States. Within South Asia, Bangladesh reported the highest preterm birth rate in 2020 at 16.2 percent, followed by Pakistan at 14.4 percent, and India at 13.0 percent. In Latin America, the rates ranged from 5.8 percent in Nicaragua to 12.8 percent in Suriname. As birth registration and facility-based deliveries have increased, data on the prevalence of preterm births has improved. Nevertheless, there are still 92 countries lacking sufficient nationally representative data. Consequently, the authors call for sustained efforts to enhance data availability, quality, and sharing to better target support and action where it is most needed. Dr. Anshu Banerjee, Director of Maternal, Newborn, Child, and Adolescent Health and Ageing at WHO, emphasized the vulnerability of preterm babies to life-threatening health complications and the necessity for dedicated care and attention. He stressed the urgency of substantial investments in services supporting preterm infants and their families, as well as a heightened focus on prevention, particularly ensuring access to quality healthcare before and during pregnancies. The researchers underscored that preterm birth is not exclusive to low and middle-income countries, as the data clearly reveals its impact on families worldwide, including some high-income countries such as Greece (11.6 percent) and the United States (10 percent).

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