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Wednesday, November 4, 2026 3:18 AM

inflammation

Every Additional 100 Grams of Ultra-Processed Food Linked to Higher Heart Disease Risk: Study

Higher consumption of ultra-processed foods (UPFs) has been associated with increased risks of several chronic health conditions, including cardiovascular disease, cancer, obesity and metabolic disorders, according to a study. The research found that greater intake of ultra-processed foods was associated with a 24 per cent higher risk of cardiovascular events, a 12 per cent higher risk of cancer and a 23 per cent higher risk of overweight or obesity. Higher consumption was also linked with increased risks of metabolic syndrome or diabetes, depression and anxiety, digestive diseases, high blood pressure and death from any cause. Ultra-processed foods are industrially manufactured products that are typically ready to eat or require minimal preparation. They often contain high levels of energy, sugar and salt while providing relatively low amounts of dietary fibre, protein, vitamins and minerals. The researchers found a dose-response relationship between UPF consumption and several health outcomes. Every additional 100 grams of ultra-processed food consumed per day was associated with an 11 per cent higher risk of hypertension, a 14 per cent higher risk of cardiovascular events, a 4 per cent higher risk of cancer and a 3 per cent higher risk of death from any cause. The study also reported that every 10 per cent increase in the share of energy intake coming from ultra-processed foods was associated with a 16 per cent higher risk of metabolic syndrome or diabetes. Researchers suggested that the potential health effects could be linked to several factors. Emerging evidence indicates that combinations of food additives may have cumulative effects, while extensive industrial processing can alter the physical structure of food and potentially affect the gut microbiome. These changes may contribute to inflammation and insulin resistance. The researchers also pointed to compounds that can form during food processing. Acrylamide, which can develop in certain foods during high-temperature processing, and acrolein, which can be generated when fats are heated, have both been associated with cardiovascular health risks. The authors noted that chronic conditions associated with high UPF consumption can occur together as multimorbidity. They suggested that reducing ultra-processed food intake and replacing such products with minimally processed alternatives could be relevant to chronic disease prevention and primary healthcare. Source: PTI

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Genefitletics Enhances Platform to Decode Cellular Health

Indian biotech startup Genefitletics has unveiled a major update to its health platform, enabling it to assess the condition of individual cells by detecting the expression of key biological signals. This advancement allows for early identification of chronic diseases—often in their asymptomatic stages—through a combination of next-generation sequencing and machine learning. According to the company, the upgraded platform now generates a “cellular health score” by analyzing markers linked to inflammation, mitochondrial function, immune activity, cellular stress, and senescence. This empowers users to monitor and improve their internal health at the cellular level. Additional capabilities include evaluations related to triglyceride regulation, risk indicators for irritable bowel disease, and a dynamic feedback system that shows how nutritional and lifestyle interventions influence biological pathways in real time. Sushant Kumar, Founder and CEO of Genefitletics, explained, “Our proprietary platform, PROTEBA, is trained on an extensive dataset—over 12 billion molecular data points, 45 million phenotype records, more than 35,000 peer-reviewed scientific publications, and continuously updated clinical insights. It now enables us to track the activity of biological pathways involved in cellular inflammation, energy inefficiency, aging, and various types of cellular stress—including oxidative, genotoxic, hypoxia-induced, and protein-misfolding stress.” This update marks a significant leap in personalized health monitoring, providing deeper insight into cellular functions and the impact of daily choices on long-term health. Source: ETHealthWorld

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The Interconnection Between Climate Change and Immune Health: A Growing Concern

As the global community grapples with the multifaceted challenges of climate change, a concerning trend has emerged: a rise in immune-mediated diseases. From nasal allergies to rheumatoid arthritis to cancer, diseases linked to immune dysregulation are on the ascent, and climate change appears to be a contributing factor. A recent study led by Harvard T.H. Chan School of Public Health sheds light on this critical issue, highlighting the profound implications of climate-driven stressors on human health. The study, published in Frontiers in Science and co-authored by Kari Nadeau, a leading expert in climate and population studies, underscores the intricate interplay between environmental factors and immune health. Climate-driven stressors, such as wildfires, extreme weather events, and changes in agricultural practices, are triggering immune dysregulation, thereby exacerbating the prevalence of immune-mediated diseases. Nadeau’s research elucidates the mechanisms through which climate change impacts immune health. For instance, pollutants from wildfires and heightened pollen levels due to warmer temperatures can compromise the body’s defense mechanisms, leaving individuals more susceptible to infections and allergic reactions. Moreover, disruptions in food production and nutrient depletion resulting from climate-related events contribute to malnutrition, impairing immune system function and exacerbating the risk of disease. Of particular concern is the role of persistent inflammation induced by climate-related stressors in driving immune-mediated diseases, including cancer. As temperatures rise and extreme weather events become more frequent, the prevalence of chronic inflammation poses a significant public health challenge, necessitating urgent action to mitigate its impact. To address the global rise in immune-mediated diseases, Nadeau advocates for a multifaceted approach. This includes implementing policies to curb greenhouse gas emissions, promoting sustainable agricultural practices, and investing in research to better understand the complex interactions between climate change and immune health. Additionally, she underscores the importance of public awareness and education, urging scientists, clinicians, policymakers, and the media to communicate the tangible health consequences of climate change to the general public. The study by Harvard T.H. Chan School of Public Health highlights the pressing need to address the intersection of climate change and immune health. By recognizing the profound impact of environmental factors on human well-being, we can galvanize collective action to safeguard public health in the face of a changing climate. As we strive to build a more resilient and sustainable future, prioritizing the protection of immune health must remain a central tenet of our global health agenda.

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