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Daily Almond Intake of 60 Grams Found to Shield DNA and Combat Oxidative Stress

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Almonds may be more than just a crunchy snack — they could be a powerful ally in protecting your health at the cellular level. New research suggests that consuming at least 60 grams of almonds a day can significantly reduce oxidative stress and safeguard DNA from damage. Oxidative stress, caused by an overload of harmful free radicals, accelerates aging, inflammation, and chronic disease risk. Almonds, rich in vitamin E, antioxidants, flavonoids, and healthy fats, act as natural defenders, helping neutralize these free radicals and strengthening the body’s resilience. According to the study, individuals who included over 60 grams of almonds in their daily diet showed notable improvements in antioxidant activity and reduced markers of oxidative stress. This directly translates into better DNA protection, healthier cells, and potentially slower signs of aging. Earlier clinical evidence also supports this. A landmark randomized trial with young male smokers who consumed 84 g of almonds daily recorded a 28% drop in oxidative DNA damage, a 34% reduction in lipid peroxidation, and a 23% decline in DNA strand breaks, proving almonds’ protective benefits even under high-stress conditions. The “60 g threshold” is now being recognized as a key benchmark. That’s about 40–45 almonds per day, roughly two servings — enough for the bioactive compounds in almonds to activate their strongest protective effects. While smaller amounts still offer health benefits, crossing this intake level seems to unlock greater antioxidant potential. Beyond heart and brain health, almonds are emerging as a natural superfood for DNA protection. Their vitamin E helps shield cell membranes, while polyphenols and flavonoids reduce inflammation and support vascular health. Together, they slow down cellular wear and tear linked to aging, cancer, diabetes, and cardiovascular disease. Experts emphasize that consistency is crucial. Incorporating almonds daily — whether eaten raw, roasted, blended into smoothies, or sprinkled over meals — makes it easy to hit the 60 g mark. This growing body of evidence reinforces almonds as more than a nutritious snack: they are a long-term investment in wellness, helping preserve genetic material, reduce disease risks, and support healthier aging. Source: TOI

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IISc Study Warns of Bird Flu Strain’s Rising Threat to Humans

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Researchers at the Indian Institute of Science (IISc) have raised concerns that the currently circulating H5N1 bird flu strain could be evolving to pose a greater risk to humans. The team, led by Kesavardhana Sannula from the Department of Biochemistry, found that the 2.3.4.4b clade of H5N1 carries genetic mutations similar to those seen in past pandemic influenza strains, enhancing its ability to adapt to human hosts. The study revealed that viruses capable of infecting foxes may have a higher human adaptation potential than those infecting cattle — a surprising finding. H5N1, first detected in birds about 30 years ago, has since caused sporadic human infections and widespread fatalities in birds and mammals, making it a panzootic concern. Using computational analysis of thousands of protein sequences from birds, mammals, and human influenza viruses, the researchers identified mutations concentrated in the viral polymerase complex (PA, PB2), nucleoproteins, and haemagglutinin (HA) proteins — key elements that could aid the virus in crossing the species barrier. The findings underscore the need for heightened surveillance and preparedness to mitigate potential outbreaks. Source: Indian Express

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Breakthrough in Understanding Childhood Immunity to Strep A Could Accelerate Vaccine Development

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A team of scientists has uncovered how young children naturally build immunity against Group A Streptococcus (Strep A), a bacterial infection responsible for up to half a million deaths worldwide each year. The finding could significantly speed up the creation of a life-saving vaccine. Strep A is a common bacterium that can cause mild illnesses like sore throat and skin infections, but in severe cases, it can trigger life-threatening diseases. While deaths from Strep A are rare in wealthier nations, outbreaks can be devastating. In late 2022, a surge in cases across the UK and Europe claimed hundreds of lives, including those of many children. The burden is far greater in low- and middle-income countries, where thousands die annually from the infection. Researchers from the University of Sheffield, working with the Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine, tracked how Gambian children acquire natural immunity. Published in Nature Medicine, the study identified specific antibodies linked to protection from Strep A, marking a crucial step toward vaccine design. The team observed that babies are born with some immunity passed down from their mothers, but this protection fades quickly. Young children, however, develop robust antibody responses to different components of the bacteria after repeated exposure. This discovery pinpoints a key window for immune development, which could guide more effective vaccination strategies. Lead researcher Dr. Alex Keeley said this is the first time scientists have seen in humans how antibodies generated through vaccination might prevent Strep A infections. Gambian scientist Fatouamta Camara described the infection’s “devastating burden” on communities and expressed hope that a vaccine could break the cycle of illness and socio-economic hardship. The research was a collaboration between Sheffield’s Florey Institute of Infection and the GSK Vaccine Institute for Global Health. Professor Thushan de Silva, who co-directed the study, emphasised the importance of cross-institutional efforts in delivering impactful global health research. Source: PTI

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WHO Urges Boost in TB Research and Innovation to Tackle High Burden in South-East Asia

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The World Health Organization (WHO) has issued an urgent call to enhance research, innovation, and regional cooperation to eliminate tuberculosis (TB) in the South-East Asia region — a region that continues to carry nearly half of the global TB burden. Speaking at the launch of a three-day virtual workshop focused on advancing TB research and innovation, Dr. Catharina Boehme, Officer-in-Charge for WHO South-East Asia, emphasized that in 2023 alone, the region saw nearly 5 million new TB cases and around 600,000 related deaths. The workshop brings together national TB programme leaders, scientists, civil society members, and global partners to push forward efforts aligned with the WHO’s End TB Strategy. The Need for Urgency and Collaboration Dr. Boehme highlighted that ending TB demands the rapid adoption of new tools, diagnostics, and treatments — and, more importantly, equitable and timely access to these innovations. “Collaboration is key to scaling up impact and ensuring that no one is left behind,” she stated. Despite a post-COVID-19 rebound in TB case detection in 2023, current progress is falling short of the End TB Strategy’s 2030 goals: a 90% drop in TB-related deaths and an 80% decline in incidence compared to 2015. Alarmingly, TB has returned as the world’s leading cause of death from a single infectious disease, with its effects disproportionately hitting the poorest and most vulnerable communities. In South-East Asia, between 30% and 80% of TB-affected households experience catastrophic healthcare expenses, pointing to the urgent need for inclusive, people-first approaches and stronger social protection systems. Signs of Progress Amidst Challenges Still, there are signs of advancement. In 2023, the region recorded 3.8 million new or relapsed TB cases, with an 89% treatment success rate among those who began treatment in 2022. The number of undiagnosed cases was significantly reduced — down to 22% from 44% in 2020. Countries are increasingly adopting technology-driven solutions such as artificial intelligence for detecting TB, digital adherence tools to monitor treatment, and direct benefit transfers to ease patients’ financial burdens. These innovations are being powered by strong political will and national commitment. Several countries have also expanded research efforts. Bangladesh has concluded a national patient cost survey, while India’s RATIONS study provided valuable insights on the role of nutrition in TB prevention and recovery. Nepal’s “TB-Free Pallika” initiative and Myanmar’s multisectoral coordination model are examples of community-led innovations that prioritize vulnerable populations. According to WHO, over 3,000 TB-related research papers were published by South-East Asian countries in the past six years, with 60% being original research. However, the challenge lies in transforming these findings into action, as knowledge gaps and lack of collaborative platforms hinder broader impact. Strengthening Regional and Global Coordination The workshop will also focus on building stronger South-South collaboration, vaccine readiness, use of digital tools for patient care, and tackling vaccine hesitancy. Discussions will revolve around aligning regulatory frameworks, improving knowledge-sharing platforms, and setting research priorities that address underlying drivers of TB — such as malnutrition and climate-related risks. Dr. Boehme noted the growing threat posed by drug-resistant TB and emphasized the importance of ensuring that scientific progress benefits everyone equally. “Access to new vaccines, medicines, and diagnostics must be equitable. Reaching underserved communities through proactive case-finding and offering socio-economic support is essential in mitigating the financial toll of TB,” she concluded. Source: PTI Photo Credit: Getty Images

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Manipal Hospitals Seeks CCI Approval to Acquire Sahyadri Hospitals in Rs 6,400 Crore Deal

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Manipal Hospitals has approached the Competition Commission of India (CCI) seeking approval to acquire Pune-headquartered Sahyadri Hospitals in a deal estimated to be worth between ₹6,200 crore and ₹6,400 crore. The transaction involves purchasing up to 100% equity in Sahyadri Hospitals Pvt Ltd through multiple tranches, according to the regulatory filing. Though the official deal value has not been disclosed, industry insiders peg the acquisition around ₹6,400 crore. The seller, Ontario Teachers’ Pension Plan Board, a Canada-based global investor, had acquired a majority stake in Sahyadri Hospitals in 2022. In a joint statement, both healthcare entities noted that the transaction is unlikely to impact competition in any significant way, allowing the CCI flexibility in defining relevant markets. They emphasized that the deal poses no appreciable adverse effect on competition (AAEC) in the Indian healthcare sector. Manipal Hospitals, headquartered in Bengaluru, recently confirmed that it had signed definitive agreements with Ontario Teachers’ for the takeover. The move is a significant step toward expanding Manipal’s reach in western India. With the acquisition of Sahyadri’s 11 hospitals located across Pune, Nashik, Ahilya Nagar, and Karad, Manipal’s total hospital count will rise to 49, with a combined capacity of approximately 12,000 beds — placing it among the largest hospital networks in the country. Commenting on the development, Dilip Jose, MD & CEO of Manipal Health Enterprises, said, “This acquisition aligns with our goal of enhancing access to quality healthcare across India. Supported by our stakeholders, including Temasek, we look forward to serving a broader patient base.” Ranjan Pai, Chairman of Manipal Education and Medical Group (MEMG), added that the expansion will significantly bolster the group’s presence in Maharashtra and western India. Manipal Hospitals is backed by Singapore-based investment firm Temasek, which manages a portfolio valued at around USD 324 billion as of March 2025. Ontario Teachers’, with assets totaling USD 266.3 billion as of December 2024, exits Sahyadri after helping it become one of Maharashtra’s leading hospital chains with over 1,400 beds. This strategic acquisition marks a major milestone in Manipal’s ongoing mission to build a truly pan-India healthcare network. Source: PTI

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Meenakshi Hospital Uses CRRT to Save Eight Critically Ill Patients in Thanjavur

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In a significant medical achievement, Meenakshi Hospital in Thanjavur has successfully saved the lives of eight critically ill patients using Continuous Renal Replacement Therapy (CRRT), a specialised form of dialysis designed for patients in intensive care. Dr. S. Gowri Shankar, Consultant Nephrologist at the hospital, revealed that the treatment was administered over the past few months to patients suffering from life-threatening kidney failure and other complications. Among the cases, one particularly severe patient—a 40-year-old man with a history of heavy alcohol consumption and smoking—was admitted with dangerously low blood pressure and critically high creatinine levels, indicating severe kidney distress. The patient, who was reliant on two inotropic drugs to sustain heart function and stabilize blood pressure, was immediately started on CRRT. This method of dialysis, unlike conventional hemodialysis, operates continuously over a 24-hour period, gently filtering the blood while preserving cardiovascular stability—crucial for patients with unstable conditions. Remarkably, within 24 hours of initiating CRRT, the patient’s vital signs began to stabilize. By the second day, his urine output—a key indicator of kidney recovery—increased significantly, and his creatinine levels returned to a safer range, indicating a strong turnaround in his condition. CRRT is particularly beneficial for patients experiencing multi-organ dysfunction or conditions such as sepsis, heart failure, severe liver issues, or dysautonomic shock, where the body fails to regulate blood pressure effectively. The therapy provides a controlled and gradual process of fluid and toxin removal, making it a safer alternative for critically ill individuals who cannot tolerate the more aggressive traditional dialysis methods. Dr. Gowri Shankar emphasized that CRRT’s ability to stabilize patients while supporting failing kidneys is proving to be a game-changer in critical care nephrology, especially for high-risk patients in intensive care units. Source: The Hindu  

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India Records Over 7,000 Suspected Heatstroke Cases and 14 Confirmed Deaths Amid Rising Temperatures

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Between March 1 and June 24, 2025, India recorded 7,192 suspected cases of heatstroke and 14 confirmed deaths due to extreme heat, according to data obtained by PTI through the Right to Information (RTI) Act. The information, provided by the National Centre for Disease Control (NCDC), points to a growing public health concern amid soaring temperatures, as India experiences one of its hottest years on record since 1901. Majority of Heatstroke Cases Reported in May May proved to be the most critical month, with 2,962 suspected cases and three confirmed deaths. In April, there were 2,140 suspected cases and six confirmed fatalities, while March saw 705 cases and two deaths. Up to June 24, June added another 1,385 suspected cases and three confirmed fatalities. Andhra Pradesh emerged as the worst-hit state, reporting 4,055 suspected cases — more than half the national total during the period. Other significantly affected states included Rajasthan (373 cases), Odisha (350), Telangana (348), and Madhya Pradesh (297). Gaps in Death Reporting Highlight Systemic Flaws Despite the high number of suspected cases, many states, including those with hundreds of reported incidents, recorded few or no confirmed deaths. Maharashtra and Uttarakhand topped the list of confirmed fatalities, each reporting three deaths. Telangana, Odisha, Tamil Nadu, Jharkhand, Uttar Pradesh, and West Bengal each reported one. Experts and officials say the actual toll is likely much higher than reported due to systemic shortcomings in data collection and diagnosis. NCDC’s figures are based on reports from hospitals under the Integrated Disease Surveillance Programme (IDSP), leaving out cases that go untreated or undiagnosed, especially those occurring outside medical facilities. A health ministry official, speaking anonymously, acknowledged these limitations: “We only capture a fraction of real cases. Many deaths go unclassified due to lack of capacity, staff, and timely reporting in hospitals.” Inconsistent Records Across Agencies India’s fragmented approach to tracking heat-related illnesses was further exposed in a PTI investigation. For the 2015–2022 period, three government agencies reported vastly different numbers: NCDC cited 3,812 heat-related deaths, the National Crime Records Bureau (NCRB) recorded 8,171, and the India Meteorological Department (IMD) listed 3,436. Discrepancies are further worsened by states failing to provide complete or timely data. In previous years, Delhi, Uttar Pradesh, Punjab, Haryana, Bihar, Karnataka, Kerala, Chhattisgarh, and West Bengal have all been inconsistent in their reporting, with some reportedly underreporting deaths to avoid paying compensation. Heat-Related Deaths Often Misclassified Abhiyant Tiwari, Climate Resilience and Health Lead at NRDC India, emphasized the difficulty of accurately linking deaths to heat exposure. “Many are recorded as heart attacks or other conditions. To understand the true impact, we must look at excess mortality during heatwaves,” he said. Soumya Swaminathan, advisor to the Health Ministry, echoed the call for reform. “We need stronger death certification and reporting systems. Reliable data is essential for shaping effective climate and health policies,” she noted. As climate change intensifies the frequency and severity of heatwaves, the lack of a unified, robust national surveillance system remains a serious barrier to India’s readiness and response. Source: Economic Times  

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Chikungunya Risk Grows: WHO Warns of Possible Global Outbreak

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The World Health Organization (WHO) has issued a global health alert about the rising threat of a chikungunya epidemic, warning that the virus could soon spread across continents if swift preventive measures are not taken. The warning, issued on Tuesday, highlights signs similar to those observed before the large-scale outbreak of 2004–05. Dr. Diana Rojas Alvarez, a medical officer at the WHO, revealed that approximately 5.6 billion people across 119 countries are potentially vulnerable. Speaking at a press conference in Geneva, she emphasized the virus’s ability to trigger severe fever, debilitating joint pain, and long-lasting health issues, particularly among older adults. Outbreak Timeline and Spread The ongoing surge began in early 2025, primarily affecting regions in the Indian Ocean, including La Réunion, Mayotte, and Mauritius—where nearly one-third of La Réunion’s population has been infected. The virus has since made inroads into Madagascar, Somalia, Kenya, India, and other parts of Southeast Asia. Alarmingly, southern Europe is now reporting isolated locally transmitted cases in France and Italy. Understanding Chikungunya Chikungunya, first identified in Tanzania in 1952, is a mosquito-borne viral illness transmitted mainly by Aedes aegypti and Aedes albopictus mosquitoes. These vectors also spread other diseases like dengue and Zika. Common symptoms include: Sudden onset of high fever Severe joint and muscle pain Headache Fatigue Rash Although the infection is rarely fatal, many patients suffer prolonged joint discomfort that can persist for months. There is currently no specific antiviral treatment. Supportive care—hydration, rest, and pain relief—remains the primary approach. While two vaccines have been approved or recommended in select countries, widespread access and deployment remain limited. The WHO is assessing safety data and global needs to determine the potential for broader rollout. Global Numbers and Trends The European Centre for Disease Prevention and Control (ECDC) reports that, as of June 2025, Brazil leads with over 141,000 cases, followed by Argentina (2,521), Peru (46), and Bolivia (605). The French territory of La Réunion has documented over 51,000 cases by May-end. In South Asia, more than 33,000 infections have been reported in India, Pakistan, and Sri Lanka since June. Notably, regions that were once free from local chikungunya transmission are now witnessing occasional local outbreaks—a shift attributed to global warming and the changing habitats of mosquito species. WHO’s Call to Action To prevent chikungunya from escalating into a full-scale global epidemic, the WHO has urged governments and health agencies to: Enhance mosquito surveillance and vector control Strengthen healthcare infrastructure for better outbreak detection and response Increase public awareness on mosquito bite prevention Accelerate vaccine research and availability The WHO stressed that delaying action now could result in a wider, more difficult-to-control health emergency in the near future. Source: Business Standard

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ICMR Opens Door for Commercial Production of Next-Gen Malaria Vaccine

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The Indian Council of Medical Research (ICMR) has announced a major step forward in the fight against malaria by inviting expressions of interest (EoI) from eligible companies and manufacturers for the commercial production of a breakthrough malaria vaccine, AdFalciVax. Developed by the ICMR’s Regional Medical Research Centre in Bhubaneswar, this recombinant chimeric multi-stage vaccine targets Plasmodium falciparum, the deadliest malaria parasite, offering both individual protection and reduced community transmission. Pre-clinical validation of the vaccine technology was carried out in collaboration with ICMR-NIMR (National Institute of Malaria Research), other ICMR institutes, and the National Institute of Immunology in Delhi, which operates under the Department of Biotechnology. ICMR-RMRCBB will provide technical know-how and hands-on support throughout the vaccine production process to ensure a smooth and efficient pathway to commercialisation. Furthermore, ICMR’s team of seasoned scientists will assist in product development, study design, protocol development, data and results analysis, efficacy and safety assessments, and necessary improvements, based on mutual agreement with the collaborating partner. This initiative marks a significant stride in India’s effort to eliminate malaria through indigenous innovation and collaborative biotech development. Source: PTI

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UK Scientists Achieve Breakthrough with Birth of 8 Healthy Babies Using Three-Person IVF

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In a landmark achievement for reproductive medicine, British researchers have successfully delivered eight babies free of mitochondrial disease through an advanced fertility technique known as three-person IVF. This innovative procedure combines the genetic material of two parents with healthy mitochondria from a donor egg, offering new hope to families battling hereditary mitochondrial conditions. The pioneering work was conducted at Newcastle University, which remains the only UK clinic licensed to perform the treatment under regulations set by the Human Fertilisation and Embryology Authority (HFEA). Among 22 high-risk women who underwent the procedure, seven pregnancies were successful, leading to the birth of eight healthy infants—four boys and four girls, including one set of twins. How Three-Person IVF Works Also referred to as mitochondrial donation, the procedure involves extracting the nuclear DNA from a fertilized egg—containing genetic material from both biological parents—and transferring it into a donor egg that has had its nucleus removed but retains healthy mitochondria. This creates an embryo with the parents’ genes and functional mitochondria from the donor. Because mitochondrial DNA accounts for just a tiny fraction (0.02–1%) of the total genome, this method does not influence the child’s physical traits or personality. Instead, it eliminates the risk of severe, often fatal diseases associated with dysfunctional mitochondria, such as organ failure or neurological disorders. Clinical Results and Safety The clinical data is promising. Five of the eight babies showed no trace of mutated mitochondria, while the remaining three had only minimal levels (5–16%)—well below the 80% threshold that typically leads to disease. All infants are developing normally, hitting age-appropriate milestones, with only a few minor, non-mitochondrial-related health issues reported. These results, published in the New England Journal of Medicine, affirm the therapy’s safety and efficacy in preventing genetic transmission of mitochondrial disorders. A Regulated Path Forward The UK became the first nation to legalize mitochondrial donation in 2015, with clinical implementation starting in 2017. Since then, only women who are highly likely to pass on mitochondrial diseases have been approved for treatment, and each case is subject to rigorous ethical and medical review. By mid-2025, around 35 women had been cleared to receive this therapy. A Future of Promise and Caution While this scientific milestone brings much-needed optimism to affected families—some of whom have lost children to mitochondrial disease—experts are advocating for continued long-term follow-up. This is especially important because mitochondrial DNA is inherited maternally, meaning that any girls born from this technique could pass the donor mitochondria on to future generations. The balance between innovation and caution remains vital, but the success of these eight births signals a significant step toward eradicating certain inherited diseases and advancing assisted reproduction. Source: TOI

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