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Wednesday, October 7, 2026 9:21 AM

healthcare

FDA Approves First-Ever Cholesterol-Lowering Pill Targeting PCSK9 for High-Risk Patients

The U.S. Food and Drug Administration (FDA) has approved Lipfendra, a groundbreaking oral medication developed by Merck, marking the first pill designed to lower cholesterol by targeting the PCSK9 protein. Until now, this treatment approach was available only through injectable medicines. The newly approved drug is intended for patients whose LDL (“bad”) cholesterol remains elevated despite taking statins, the standard treatment for reducing the risk of heart attacks and other cardiovascular diseases. Lipfendra works by blocking the PCSK9 protein in the liver, allowing the body to remove more LDL cholesterol from the bloodstream. Existing PCSK9 therapies, offered as injections by several pharmaceutical companies, have been effective for years but have faced challenges related to high costs, insurance barriers, and limited patient access. Merck secured FDA approval after positive results from two clinical trials involving high-risk patients who received Lipfendra in addition to their regular cholesterol-lowering therapy. In one study involving around 3,000 participants, patients experienced a reduction of more than 55% in LDL cholesterol after six months. A second trial showed an average 59% decrease in LDL levels compared with those receiving a placebo. The cholesterol-lowering effect remained largely consistent over a year of treatment. Researchers reported that side effects, including dizziness and diarrhea, were generally mild and occurred at rates similar to those seen with the placebo. Patients are advised to take the medication on an empty stomach for optimal effectiveness. The FDA reviewed Lipfendra under its accelerated approval programme for promising therapies that address significant public health needs, enabling a faster regulatory process. Heart disease continues to be the leading cause of death in the United States, with elevated LDL cholesterol being a major contributor to heart attacks and strokes. While an LDL level below 100 mg/dL is generally considered healthy for most individuals, experts recommend reducing it to 70 mg/dL or lower for people with heart disease or those at high cardiovascular risk. The approval of Lipfendra offers a convenient oral alternative to injectable PCSK9 inhibitors and could significantly improve access to advanced cholesterol-lowering treatment for patients who require additional LDL reduction beyond statins. Source: AP

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Novo Nordisk Introduces Once-Weekly Insulin Injection ‘Awiqli’ in India for Adults with Diabetes

Danish pharmaceutical company Novo Nordisk has launched Awiqli, its once-weekly basal insulin injection, in India, offering adults with type 1 and type 2 diabetes an alternative to conventional daily insulin therapy. The company announced the launch on July 9, with the product set to become available across the country next week. Awiqli, also known by its generic name insulin icodec, is the world’s first clinically approved once-weekly long-acting basal insulin. By requiring just 52 injections annually instead of 365, the treatment aims to improve patient convenience and adherence to insulin therapy. Novo Nordisk has priced the weekly dose of 70 insulin units at ₹261. The product will be available in two pre-filled pen formats: a 1 ml pen containing 700 units priced at ₹2,611, and a 3 ml pen with 2,100 units priced at ₹7,833. According to the company, this makes the therapy competitively priced compared to existing daily basal insulin options, which cost between ₹345 and ₹453 for an equivalent weekly dose. The company highlighted the significant diabetes burden in India, where more than 101 million people are living with diabetes, while another 136 million are estimated to have prediabetes. It also noted that insulin therapy is often initiated 7–9 years later than recommended, largely due to concerns over frequent injections, pain, and treatment costs. India currently has around 6 million people receiving insulin therapy, and Novo Nordisk expects that figure to increase to 9 million in the coming years as awareness and access improve. According to market estimates by IMARC, India’s insulin market is projected to expand from $660.5 million in 2025 to $916.4 million by 2034, supported by the rising prevalence of diabetes driven by sedentary lifestyles, unhealthy diets, and genetic factors. Earlier this year, Awiqli received regulatory approval in the United States and has also been cleared for use in the European Union and several other countries. India becomes the seventh country to introduce the once-weekly insulin. The new therapy is expected to compete with established basal insulin brands, including Sanofi’s Lantus, as well as insulin glargine products marketed by Indian pharmaceutical companies such as Biocon, Eris Lifesciences, and Lupin. Novo Nordisk is also strengthening its presence in India’s rapidly growing obesity treatment market, where it faces competition from Eli Lilly and several domestic drug manufacturers. Source: REUTERS

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AIIMS Delhi Completes Major Faculty Recruitment Drive Using Blockchain-Enabled Technology

All India Institute of Medical Sciences, New Delhi has successfully concluded one of its largest faculty recruitment drives in recent years, announcing the results for nearly 460 teaching positions through a blockchain-enabled digital evaluation system. According to the institute, around 370 faculty members have been recruited for AIIMS New Delhi and the AIIMS–Central Armed Police Forces Institute of Medical Sciences campus. The appointments span more than 50 medical and allied health disciplines, covering roles from Assistant Professor to Professor. The recruitment process attracted over 3,200 applications for 265 faculty positions at AIIMS New Delhi and 199 positions at the AIIMS-CAPFIMS campus. The selection exercise was carried out over a period of six months. AIIMS stated that the use of blockchain-enabled digital technology ensured a secure, transparent, and efficient evaluation process. Candidate assessment scores were protected using one-time password (OTP) authentication, while final merit lists were generated through predefined algorithms, reducing manual intervention and enhancing the integrity of the recruitment process. The institute noted that adopting advanced digital technologies for faculty appointments reflects its commitment to strengthening institutional governance through innovation. The large-scale recruitment is expected to enhance patient care, medical education, research, and innovation across a broad spectrum of healthcare specialties. Source: Economic Times

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Doctors Warn First-Time Adult Seizures May Signal Brain Tumours; Early Diagnosis Key to Better Outcomes

Medical experts have cautioned that seizures occurring for the first time in adulthood should not be overlooked, as they may be an early warning sign of an underlying brain tumour. The advisory comes in the wake of World Brain Tumour Day, observed on June 8, highlighting the importance of timely diagnosis and treatment. According to neurologists and oncologists, late-onset seizures are among the most significant early symptoms associated with brain tumours. Doctors stress that even a single seizure episode in an adult warrants immediate medical attention and diagnostic imaging, as it could be the first detectable indication of a tumour in the brain. Specialists note that brain tumours constitute a substantial share of central nervous system cancers reported in India. Data from the Indian Council of Medical Research’s National Cancer Registry Programme indicate that outcomes can be particularly challenging in aggressive tumour types such as gliomas, underscoring the need for early detection. Medical professionals also highlighted the progress made in brain tumour diagnosis and treatment over recent years. Advancements in high-resolution imaging, digital technologies, and neuronavigation systems have significantly improved the accuracy of diagnosis and surgical planning, enabling more effective patient care. Experts explained that brain tumours can be either benign or malignant, with treatment strategies varying based on the type, location, and stage of the tumour. Modern treatment approaches, including surgery, radiation therapy, and other targeted interventions, have improved disease management and, in some cases, offer the possibility of long-term control or cure. In addition, the growing adoption of genomic profiling and genetic sequencing is helping clinicians identify patients who may benefit from personalised treatment options. These precision medicine techniques are increasingly shaping the future of neuro-oncology by enabling therapies tailored to the molecular characteristics of individual tumours. Doctors urged the public to remain vigilant about neurological symptoms and seek medical evaluation promptly, emphasizing that early diagnosis can play a crucial role in improving treatment outcomes and quality of life for patients with brain tumours. Source: The Hindu

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​​Zydus secures USFDA orphan drug tag for sickle cell therapy Desidustat

Zydus Lifesciences has received Orphan Drug Designation from the US Food and Drug Administration (USFDA) for Desidustat, its novel oral therapy being developed for the treatment of Sickle Cell Disease (SCD), the company said on Friday. The USFDA grants orphan status to medicines intended to treat rare conditions affecting fewer than 200,000 people in the United States, with the aim of encouraging research and development in areas of high unmet medical need. Commenting on the development, Zydus Lifesciences Managing Director Sharvil Patel said the designation highlights the critical need for new treatment options for patients with sickle cell disease. He added that the company believes Desidustat has the potential to address gaps in current therapies, which remain limited. Zydus also said it has successfully completed a Phase II, double-blind, randomised, placebo-controlled, multi-centre proof-of-concept study to assess the efficacy and safety of Desidustat in patients with SCD. The clinical data from the study is expected to be published in a peer-reviewed medical journal. The orphan drug status makes Desidustat eligible for several regulatory incentives, including tax credits for clinical trials, exemption from certain USFDA user fees, and the possibility of seven years of market exclusivity in the US following regulatory approval. Source: PTI

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Scientists Explore How Music Can Help Relieve Pain from Surgery and Illness

In the recovery ward at UC San Diego Health, nurse Rod Salaysay relies on more than just medical tools like a stethoscope or thermometer — he also uses his guitar and ukulele. Between post-surgery medications, Salaysay plays tunes at patients’ request, ranging from folk songs and classical pieces like Minuet in G Major to movie classics such as Somewhere Over the Rainbow. The results are often visible: patients smile, relax, and sometimes even require fewer painkillers. “In hospitals, pain, anxiety, and worry often feed into each other,” Salaysay explained. “Music can help break that cycle.” Over the last twenty years, hospitals and clinics worldwide have increasingly turned to music therapy — both live and recorded — as studies continue to reveal its power to ease physical and emotional pain. While music’s emotional influence has long been understood, scientists are only now uncovering how music-induced analgesia — the process by which music reduces pain perception — actually works. Although a melody can’t replace strong pain medication, research published in Pain and Scientific Reports shows that listening to music can lessen pain intensity and increase a person’s tolerance to discomfort. What seems crucial, researchers say, is that patients choose the music themselves and listen attentively, rather than passively. “Pain is incredibly complex,” said Adam Hanley, a psychologist at Florida State University. “It’s shaped by both the body’s sensations and our emotional and mental responses to those sensations.” Even with the same condition, two people might experience pain differently. Acute pain comes from immediate physical triggers, while chronic pain involves long-term changes in the brain that heighten sensitivity. “Pain is processed and interpreted by the brain,” said Dr. Gilbert Chandler, a chronic spinal pain expert from Tallahassee Orthopedic Clinic, “and the brain can amplify or reduce those signals.” Music, experts note, helps redirect attention away from pain. Studies suggest that preferred music is especially effective, even more than podcasts or generic playlists. “Music doesn’t just distract — it engages the whole brain,” said Caroline Palmer, a psychologist at McGill University. “That’s why it changes how people experience pain.” Indeed, Kate Richards Geller, a Los Angeles-based music therapist, explains that engaging with music activates nearly every brain region, easing not just pain but also isolation and anxiety. The use of music for pain relief dates back to the 19th century, when patients listened to melodies during dental procedures before anesthetics were common. Modern researchers continue to explore what makes it most effective. In one experiment at Erasmus University Rotterdam, scientists tested 548 participants across five music genres — classical, rock, pop, urban, and electronic — to measure how long they could withstand cold-induced pain. All genres helped, but none outperformed the others. “The best music is simply what you like,” said study co-author Dr. Emy van der Valk Bouman, noting that familiar songs may trigger memories and emotions that enhance resilience. Allowing patients to choose their music can also restore a sense of control and agency, said Claire Howlin of Trinity College Dublin, whose research shows that self-selected songs can boost pain tolerance. Hanley’s studies further indicate that focused, daily listening may gradually reduce chronic pain, offering an uplifting “emotional bump” without side effects. For many, it’s a powerful, drug-free remedy. Cecily Gardner, a jazz vocalist from California, said music helped her cope with illness and brought comfort to others in pain. “Music reduces stress, connects people,” she said, “and transports you somewhere better.” Source: AP

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PwC India Unveils Vision 2030, to Add 20,000 Jobs and Triple Revenue in Five Years

PwC India has announced an ambitious expansion plan under its Vision 2030, aiming to grow its workforce to 50,000 employees within the next five years by creating 20,000 new jobs. The consulting major is targeting a threefold increase in revenue, committing over 5% of annual revenues to technology, innovation, and capability building. The company will sharpen its focus on areas such as digital transformation, sustainability, risk and regulatory compliance, cloud, and cybersecurity, positioning itself to help clients navigate rapid market disruptions. Chairperson Sanjeev Krishan emphasised the firm’s goal of building a “future-ready workforce,” with investments in upskilling, women in leadership, and inclusive career growth from entry-level to the boardroom. PwC India will allocate 1% of its revenues to learning initiatives while expanding its presence in Tier 2 and Tier 3 cities to support decentralised economic growth and align with the government’s vision of self-reliant local economies. Recruitment will focus on sector-specific and digital expertise, with growth anchored in six priority sectors: financial services, healthcare, industrial manufacturing, automotive, technology, media, and telecom. Additionally, the company will explore emerging “horizon sectors” to secure an early strategic foothold. Source: PTI

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PM Modi Chairs Day-Long Conclave with NDA CMs, Focuses on Good Governance and Development Synergies

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Prime Minister Narendra Modi chaired a comprehensive conclave in New Delhi, bringing together Chief Ministers and Deputy Chief Ministers from all 20 National Democratic Alliance (NDA)-governed states. The high-level meeting centred on strategies to accelerate development and ensure the effective delivery of governance through the “double-engine” model. Addressing the gathering, the Prime Minister stressed the importance of enhancing coordination and synergy across sectors such as healthcare, sanitation, agriculture, youth empowerment, and technology. He also encouraged states to intensify their efforts in delivering public services and creating impactful governance outcomes. In a post on social media, PM Modi highlighted the extensive discussions held during the conclave, which included sharing of successful models and initiatives from various states. These ranged from water conservation and grievance redressal mechanisms to administrative reforms, women empowerment, sports, and education. Organised by the BJP’s Good Governance Department, the conclave saw participation from 20 Chief Ministers and 18 Deputy Chief Ministers. Senior BJP leaders including Party President JP Nadda, Home Minister Amit Shah, and Defence Minister Rajnath Singh also took part in the day-long discussions. Speaking to the media after the meeting, BJP President JP Nadda stated that two key resolutions were adopted. The first praised the Indian armed forces for their bravery under Operation Sindoor, which targeted terror camps across the border. The second resolution reaffirmed the party’s stance on caste-based policies, clarifying that the BJP prioritises social integration and mainstreaming of backward communities without engaging in caste-based politics. The session also featured detailed presentations by the states showcasing their governance achievements. Additionally, leaders discussed preparations for major upcoming milestones, including the NDA government’s first anniversary on June 9, the 10th International Day of Yoga, and the 50th year since the declaration of the Emergency in 1975. The conclave reinforced the NDA’s collective commitment to good governance, innovation, and inclusive development across the nation. Source: newsonair  

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Delhi Govt Expands Vocational Education: Skill-Based Courses Introduced in 257 More Schools

In a significant push towards integrating vocational training into mainstream education, the Delhi government has approved the rollout of skill-based subjects in 257 additional government schools starting this academic session, as per a circular issued by the Directorate of Education on May 23. These skill subjects fall under the Samagra Shiksha initiative and aim to equip students in Classes 9 and 11 with hands-on learning and industry-relevant skills alongside their regular curriculum. Each school can enroll up to 50 students per subject, encouraging broader participation in career-oriented learning. To guide students in making informed decisions, schools have been asked to conduct counselling sessions detailing the benefits and future prospects associated with these vocational courses. Notably, students entering Class 11 can opt for a skill subject even if they haven’t studied it in the earlier grades, thanks to the policy’s flexible multi-entry and multi-exit structure. However, participation in these skill subjects remains optional, not mandatory. Schools can offer these courses as additional learning avenues without making them compulsory for all students. As per CBSE norms, schools do not require separate permissions to introduce new vocational subjects. They simply need to update the necessary information on the CBSE portal. The National Skills Qualifications Framework (NSQF) subjects being offered include practical disciplines such as Information Technology, Retail, Healthcare, and Beauty & Wellness—all designed to boost employability and prepare students for real-world careers. Source: PTI (Image: AI generated)    

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Sangam City Sees Major Healthcare Boost with New Hospitals and Facilities

Over the past eight years, the state government has made significant strides in strengthening healthcare infrastructure in Sangam City. With the expansion of both state and central health schemes, residents now have access to improved medical facilities and treatments. Dr. Vatsala Mishra, Principal of Motilal Nehru (MLN) Medical College, highlighted several key developments, including a 160-bed PMSSY Super Specialty Block at Swaroop Rani Nehru Hospital, built at a cost of ₹160 crore, benefiting patients from Prayagraj and nearby districts. Additionally, a ₹25 crore, 250-bed advanced children’s hospital is set to become operational by August. Healthcare advancements were further supported by a ₹75 crore budget from Maha Kumbh, enabling new constructions and equipment purchases. A new OPD facility was built at Swaroop Rani Nehru Hospital, while a ₹9 crore Central Diagnostic Center now offers all tests in one place. A ₹36 crore L1 Trauma Center project was also approved, with ₹16 crore allocated for modern medical equipment. Furthermore, a ₹7 crore Green Corridor was created to facilitate safe patient transfers between hospital blocks. These developments have significantly increased outpatient department (OPD) visits, now ranging between 3,000 to 4,000 per day. Beyond urban centers, healthcare services have expanded into rural areas. Three new Community Health Centers (CHCs) were established, along with a 100-bed hospital in Bhagwatpur. The district now operates 551 Ayushman Arogya Mandirs, offering primary healthcare and telemedicine consultations. Additionally, 12 Health ATMs have been installed for convenient medical testing. Under the Ayushman Bharat Pradhan Mantri Jan Arogya Yojana, 13.64 lakh golden cards have been issued, ensuring financial coverage for medical expenses. These advancements mark a transformative era in healthcare accessibility and quality in Sangam City. Source: TOI

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